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Effects of topiramate and gabapentin on cognitive abilities in healthy volunteers.

Author: DodrillC B, LandryT, OkenB S, SalinskyM C, SpencerD C, StorzbachD

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Topiramate significantly impaired cognitive performance in healthy volunteers, while gabapentin had minimal effects, suggesting that topiramate may affect daily and occupational function.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the cognitive effects of topiramate (TPM) and gabapentin (GBP). METHODS: Forty healthy volunteers were randomized to a 12-week course of TPM, GBP, or placebo. Doses were gradually escalated over 10 weeks to a maximum of 400 mg/day of TPM or 3,600 mg/day of GBP or to the highe...See full text at original site
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引用元：
https://doi.org/10.1212/01.WNL.0000152877.08088.87

データ提供：米国国立医学図書館（NLM）

Cognitive Effects of Topiramate and Gabapentin: A Comparative Study

The study of cognition, the mental processes involved in thinking, learning, and memory, is a complex and fascinating field. This study investigates the potential cognitive effects of topiramate (TPM) and gabapentin (GBP), two medications commonly used for treating epilepsy and other neurological conditions. The researchers conducted a 12-week study involving healthy volunteers, finding that TPM had a significant negative impact on cognitive performance, while GBP had minimal effects. These findings highlight the importance of considering potential cognitive side effects when prescribing these medications.

Topiramate's Impact on Cognitive Performance: A Cautionary Tale

This study provides valuable insights into the potential cognitive side effects of TPM, emphasizing the need for careful monitoring and consideration when prescribing this medication.

Topiramate's Impact on Cognitive Performance: A Cautionary Tale

Think of your brain as a vast desert oasis, teeming with activity. TPM, like a harsh sandstorm, can disrupt the normal flow of activity in the oasis, potentially impairing cognitive functions. GBP, on the other hand, is like a gentle breeze that barely disturbs the oasis's tranquility. This study highlights the importance of choosing the right medication to minimize the risk of cognitive side effects.

Dr.Camel's Conclusion

This study provides a reminder that medications, even those intended to treat serious conditions, can have unintended consequences. The careful evaluation of potential cognitive side effects is crucial for ensuring the well-being of patients.

Date :
  1. Date Completed 2006-02-09
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

15753411

DOI: Digital Object Identifier

10.1212/01.WNL.0000152877.08088.87

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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