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A randomized controlled trial of intravesical bacillus calmette-guerin for treatment refractory interstitial cystitis.

Author: , BurksDavid, CulkinDaniel J, DioknoAnanias, FosterHarris E, HannoPhilip, KusekJohn W, LandisJ Richard, MadiganRosemary, MayerRobert, MessingEdward M, NickelJ Curtis, NybergLeroy M, PayneChristopher K, PetersKenneth M, PropertKathleen Joy, SantGrannum R, WarrenJohn, WeinAlan J, ZhangYawei

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Bacillus Calmette-Guerin (BCG) instillations did not show a significant improvement in response rates compared to placebo instillations in patients with treatment-refractory interstitial cystitis (IC).
Paper Details　
Original Abstract of the Article :
PURPOSE: We compared intravesical bacillus Calmette-Guerin (BCG) to placebo instillations in patients with treatment refractory interstitial cystitis (IC). MATERIALS AND METHODS: Subjects who met the National Institutes of Health-National Institute for Diabetes and Digestive and Kidney Diseases cri...See full text at original site
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引用元：
https://doi.org/10.1097/01.ju.0000152337.82806.e8

データ提供：米国国立医学図書館（NLM）

Treating Refractory Interstitial Cystitis: A New Hope with BCG?

The challenging world of [interstitial cystitis (IC)] is always seeking new treatment options. This study investigates the potential of [intravesical bacillus Calmette-Guerin (BCG)] in treating [treatment refractory IC]. The authors conducted a [randomized controlled trial] to compare the effectiveness of [BCG] instillations to [placebo] in patients with [IC]. While the results show a trend towards improvement with [BCG], the difference in response rates was not statistically significant.

BCG for Refractory IC: Further Research Needed

The study suggests that [BCG] may have a role in managing [treatment refractory IC], but more research is needed to confirm its efficacy. The findings highlight the challenges of treating this complex condition and the need for ongoing exploration of new therapeutic options.

Living with IC: A Journey of Hope and Collaboration

This study underscores the importance of a collaborative approach to managing [IC]. It's crucial to work closely with your healthcare provider to develop a personalized treatment plan that addresses your unique needs. While [BCG] may offer some hope for individuals with [IC], ongoing research and the exploration of new treatment approaches are crucial for improving outcomes for this patient population.

Dr. Camel's Conclusion

This study is like a lone camel seeking a hidden oasis in the vast desert of [interstitial cystitis]. While [BCG] shows promise, further research is needed to determine its true potential. The journey to finding effective treatments for this challenging condition continues, and ongoing collaboration between researchers, clinicians, and patients is key to finding a solution.

Date :
  1. Date Completed 2005-04-06
  2. Date Revised 2007-11-14
Further Info :

Pubmed ID

15758738

DOI: Digital Object Identifier

10.1097/01.ju.0000152337.82806.e8

Related Literature

Article Analysis
・Effective treatment of interstitial cystitis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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