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Potential effectiveness and safety of olanzapine in refractory panic disorder.

Author: HollifieldMichael, RuizJames E, ThompsonPeter M, UhlenhuthE H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the use of olanzapine, a medication typically used for schizophrenia, in treating severe panic disorder that didn't respond to other treatments. After 8 weeks of treatment, 50% of the 10 participants were completely free of panic attacks, and 60% were free of anxiety about future attacks. Overall, there was a significant reduction in panic attacks and anticipatory anxiety. While olanzapine showed potential benefits with minimal side effects, further studies are needed to confirm its effectiveness.
Paper Details　
Original Abstract of the Article :
Panic disorder is a common and disabling psychiatric disorder. Despite treatment advances, refractory panic disorder requires novel interventions. One such pharmacologic intervention with theoretical and case study support includes olanzapine, a thienobenzodiazepine medication currently approved for...See full text at original site
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引用元：
https://doi.org/10.1002/da.20050

データ提供：米国国立医学図書館（NLM）

A New Hope for Refractory Panic Disorder

This study explores the challenging field of [panic disorder treatment], focusing on patients with refractory panic disorder, a condition that has not responded to conventional therapies. The researchers investigated the potential effectiveness of olanzapine, an atypical antipsychotic, as a novel treatment option. The study used a [flexible-dose clinical trial] to assess the effects of olanzapine on patients with refractory panic disorder.

Olanzapine Shows Promise

The results of this open-label trial suggest that olanzapine could be a [promising treatment] for patients with refractory panic disorder. The researchers observed a significant reduction in panic attacks, anticipatory anxiety, and phobic avoidance in the participants. Notably, 50% of the participants became panic-free by the end of the trial. These findings provide [encouraging evidence] for the potential of olanzapine in treating this debilitating condition.

Understanding Panic Disorder and its Impact

Panic disorder is a complex and debilitating condition that can severely impact a person's quality of life. This study highlights the need for [effective treatment options] for patients who have not responded to traditional therapies. It's like finding a way to navigate a desert storm - a safe and effective treatment can help bring calm and stability to a person's life.

Dr.Camel's Conclusion

This research offers a ray of hope for individuals struggling with refractory panic disorder. The findings suggest that olanzapine could be a valuable tool for reducing symptoms and improving quality of life. It's like discovering a hidden spring in the middle of a parched desert - finding a treatment that works can be life-changing. Further research is needed to confirm these promising results, but this study provides an important step in the journey towards better treatments for this challenging condition.

Date :
  1. Date Completed 2005-08-09
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

15786486

DOI: Digital Object Identifier

10.1002/da.20050

Related Literature

Article Analysis
・Effective treatment of panic disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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