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Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy.

Author: ElgerC E, FritzN, GlogauS, HelmstaedterC, HoffmannJ, RademacherM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Newer antiepileptic drugs are effective, but their cognitive side effects are still being studied. A randomized trial compared the cognitive effects of two newer antiepileptic drugs, TPM and TGB, on cognition, mood, and health-related quality of life.
Paper Details　
Original Abstract of the Article :
Whereas the efficacy of the newer antiepileptic drugs (AEDs) is well established, there remain questions regarding their cognitive side effects. Therefore, we performed a comparative open randomized trial with TPM and TGB as add-on therapy, with particular consideration of cognition, mood, and healt...See full text at original site
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引用元：
https://doi.org/10.1016/j.yebeh.2005.01.002

データ提供：米国国立医学図書館（NLM）

Tiagabine and Topiramate: A Comparative Study of Epilepsy Treatments

Epilepsy, a neurological disorder characterized by seizures, can significantly disrupt daily life. This study investigates the efficacy and cognitive side effects of two antiepileptic drugs (AEDs), tiagabine (TGB) and topiramate (TPM), when used as add-on therapy for patients with epilepsy. The researchers conducted a comparative open randomized trial, focusing on the impact of these AEDs on cognition, mood, and overall quality of life.

Comparing Tiagabine and Topiramate: A Quest for Effective and Safe Epilepsy Treatments

The study provides valuable insights into the comparative efficacy and cognitive side effects of TGB and TPM as add-on therapy for epilepsy. While both medications demonstrated efficacy in controlling seizures, the researchers observed differences in their impact on cognition, mood, and overall quality of life. This research highlights the importance of carefully considering the potential benefits and risks of different AEDs, tailoring treatment plans to individual patient needs and preferences.

Navigating Epilepsy Treatment: Finding the Right Balance

Living with epilepsy often involves a delicate balancing act between controlling seizures and managing potential side effects. It's important to discuss your concerns and preferences with your doctor, considering the potential impact of different AEDs on your cognitive function, mood, and overall quality of life. Close monitoring of your condition and open communication with your healthcare provider can help ensure optimal treatment and improve your overall well-being.

Dr.Camel's Conclusion

This research, like a camel seeking the most nourishing oasis in a diverse desert landscape, explores the comparative efficacy and cognitive side effects of different epilepsy treatments. The study emphasizes the need for individualized approaches to epilepsy management, considering the unique needs and preferences of each patient. By understanding the potential benefits and risks of different AEDs, we can strive for effective seizure control while minimizing the impact on cognitive function, mood, and overall quality of life.

Date :
  1. Date Completed 2005-06-06
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

15820346

DOI: Digital Object Identifier

10.1016/j.yebeh.2005.01.002

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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