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A pilot, double-blind, placebo-controlled trial of indinavir in patients with ALS.

Author: DelBeneM, ImperatoT, KimM Y, LeValleyA J, LiuM H, MacGowanD J L, MitsumotoH, ScelsaS N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Indinavir, a protease inhibitor used to treat HIV-1 infection, was investigated in a trial for patients with amyotrophic lateral sclerosis (ALS). While indinavir was generally safe, it was not effective in treating ALS and caused nephrolithiasis (kidney stones) and gastrointestinal side effects.
Paper Details　
Original Abstract of the Article :
There is some evidence of retroviral infection in ALS. A randomized, double-blind, placebo-controlled trial of indinavir in ALS was performed to assess safety and efficacy trends. Nephrolithiasis and gastrointestinal side effects were frequent with indinavir treatment. Group differences in the rate ...See full text at original site
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引用元：
https://doi.org/10.1212/01.WNL.0000156913.24701.72

データ提供：米国国立医学図書館（NLM）

Indinavir: A False Oasis for ALS Treatment?

Amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, has been a perplexing enigma in the world of medicine. This pilot, double-blind, placebo-controlled trial investigated the potential of indinavir, an antiretroviral medication, as a treatment for ALS. The study, while small in scale, revealed some concerning findings. Indinavir treatment was associated with frequent nephrolithiasis (kidney stones) and gastrointestinal side effects. Furthermore, no significant difference in the rate of disease progression was observed between the indinavir group and the placebo group. These results highlight the need for caution in considering indinavir as a treatment for ALS and underscore the importance of continued research to find safe and effective therapies for this debilitating condition.

A Mirage in the Desert: The Challenges of ALS Treatment

This study serves as a reminder of the ongoing challenges in finding effective treatments for ALS. While indinavir showed no significant benefit and was associated with adverse effects, the search for effective treatments for ALS continues. This research emphasizes the importance of rigorous clinical trials to evaluate the safety and efficacy of potential treatments before they are widely adopted.

The Desert of ALS: A Persistent Search for Solutions

This study highlights the ongoing search for effective treatments for ALS. While indinavir showed no significant benefit and was associated with adverse effects, the quest for effective therapies for ALS continues. This research emphasizes the importance of rigorous clinical trials to evaluate the safety and efficacy of potential treatments before they are widely adopted.

Dr.Camel's Conclusion

This pilot study highlights the complexity of finding effective treatments for ALS. While indinavir showed no significant benefit and was associated with adverse effects, the quest for effective therapies for ALS continues. The study emphasizes the importance of rigorous clinical trials to evaluate the safety and efficacy of potential treatments before they are widely adopted.

Date :
  1. Date Completed 2006-02-10
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15824372

DOI: Digital Object Identifier

10.1212/01.WNL.0000156913.24701.72

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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