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Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect.
Author: DavenportAnthony, EdvinssonLars, LongmoreJenny, MalmsjöMalin, UddmanErik, WackenforsAngelica
Original Abstract of the Article :
Triptans are agonists at 5-HT1B and 5-HT1D (where 5-HT is 5-hydroxytryptamine; serotonin) receptors and cause vasoconstriction of isolated blood vessels. The aim of the present study was to determine vasoconstrictor potency (EC50) of triptans in human coronary and cerebral arteries and to examine wh...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1042/CS20050016
データ提供:米国国立医学図書館(NLM)
Triptans: Navigating the Vasoconstriction Desert
The world of migraine treatment is often a challenging landscape, with many different approaches and varying effectiveness. This study investigates the vasoconstrictor effects of triptans, a class of drugs commonly used to treat migraines, on human cerebral and coronary arteries. The study uses a meticulous approach to map out the specific pathways by which triptans exert their effects, revealing their selective vasoconstriction of cerebral arteries over coronary arteries. The research also uncovers the fascinating connection between vasoconstrictor potency in cerebral arteries and clinically relevant plasma levels.
A Map to Effective Migraine Treatment
This research provides a valuable map to the effectiveness of triptans in treating migraines. The study's findings suggest that triptans exert a selective vasoconstrictive effect on cerebral arteries, potentially explaining their effectiveness in relieving migraine symptoms.
Understanding Triptans: A Guide for Migraine Sufferers
This research offers valuable insight into the mechanism of action of triptans, a common treatment for migraines. It underscores the importance of understanding the potential cardiovascular effects of triptans and the need for careful monitoring by healthcare professionals.
Dr. Camel's Conclusion
This study sheds light on the complex world of triptans and their effects on the human body. By mapping the intricate pathways of vasoconstriction, the research provides a roadmap for understanding the effectiveness and potential risks associated with these medications. It underscores the importance of personalized approaches to migraine treatment and the need for continued research to unravel the mysteries of this debilitating condition.
Date :
- Date Completed 2005-12-13
- Date Revised 2014-11-20
Further Info :
Related Literature
English
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