Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect.

Author: DavenportAnthony, EdvinssonLars, LongmoreJenny, MalmsjöMalin, UddmanErik, WackenforsAngelica

Paper Details 
Original Abstract of the Article :
Triptans are agonists at 5-HT1B and 5-HT1D (where 5-HT is 5-hydroxytryptamine; serotonin) receptors and cause vasoconstriction of isolated blood vessels. The aim of the present study was to determine vasoconstrictor potency (EC50) of triptans in human coronary and cerebral arteries and to examine wh...See full text at original site
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引用元:
https://doi.org/10.1042/CS20050016

データ提供:米国国立医学図書館(NLM)

Triptans: Navigating the Vasoconstriction Desert

The world of migraine treatment is often a challenging landscape, with many different approaches and varying effectiveness. This study investigates the vasoconstrictor effects of triptans, a class of drugs commonly used to treat migraines, on human cerebral and coronary arteries. The study uses a meticulous approach to map out the specific pathways by which triptans exert their effects, revealing their selective vasoconstriction of cerebral arteries over coronary arteries. The research also uncovers the fascinating connection between vasoconstrictor potency in cerebral arteries and clinically relevant plasma levels.

A Map to Effective Migraine Treatment

This research provides a valuable map to the effectiveness of triptans in treating migraines. The study's findings suggest that triptans exert a selective vasoconstrictive effect on cerebral arteries, potentially explaining their effectiveness in relieving migraine symptoms.

Understanding Triptans: A Guide for Migraine Sufferers

This research offers valuable insight into the mechanism of action of triptans, a common treatment for migraines. It underscores the importance of understanding the potential cardiovascular effects of triptans and the need for careful monitoring by healthcare professionals.

Dr. Camel's Conclusion

This study sheds light on the complex world of triptans and their effects on the human body. By mapping the intricate pathways of vasoconstriction, the research provides a roadmap for understanding the effectiveness and potential risks associated with these medications. It underscores the importance of personalized approaches to migraine treatment and the need for continued research to unravel the mysteries of this debilitating condition.

Date :
  1. Date Completed 2005-12-13
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

15853772

DOI: Digital Object Identifier

10.1042/CS20050016

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English

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