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Palliation of bone pain in prostate cancer using chemotherapy and strontium-89. A randomized phase II study.

Author: EdgrenMaliha, GinmanClaes, KälknerKarl-Mikael, NilssonSten, NordströmBritta, RybergMarianne, StrangPeter, WestlinJan-Erik, ZimmermannRolf

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Strontium-89 and chemotherapy (FEM) were equally effective in reducing bone pain in patients with hormone-refractory prostate cancer, but chemotherapy had significantly more severe side effects.
Paper Details　
Original Abstract of the Article :
Strontium-89 is an established alternative for the alleviation of bone pain in prostate cancer. There are few data evaluating the effect on pain of palliative chemotherapy. The aim of this randomized phase II study was to assess and compare the analgesic efficacy of strontium-89 and chemotherapy (FE...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpainsymman.2004.07.008

データ提供：米国国立医学図書館（NLM）

Easing Bone Pain in Prostate Cancer: A Comparative Approach

Prostate cancer, like a relentless desert storm, can cause significant bone pain. This study, like a compassionate traveler offering solace, explores two different approaches to alleviating bone pain in patients with prostate cancer. It compares the effectiveness of strontium-89 and chemotherapy, aiming to identify the most effective treatment option for pain relief. The findings show that both strontium-89 and chemotherapy were successful in reducing pain intensity and frequency, offering a glimmer of hope for patients facing this challenging condition. However, the study also notes a significant difference in the severity of side effects, with chemotherapy causing more severe side effects compared to strontium-89.

Strontium-89: A Potential Alternative for Bone Pain Relief in Prostate Cancer

The study found that strontium-89 was equally effective as chemotherapy in reducing pain intensity and frequency in patients with prostate cancer, but with significantly fewer side effects. This suggests that strontium-89 could be a valuable alternative for patients seeking pain relief with a lower risk of adverse reactions.

Managing Bone Pain in Prostate Cancer: A Compassionate Approach

This study provides valuable information for patients and physicians navigating the complex landscape of prostate cancer treatment. It emphasizes the importance of considering the individual needs and preferences of each patient, carefully weighing the potential benefits and risks of different treatment options. Remember, just as a compassionate desert traveler offers assistance to those in need, providing effective pain management for prostate cancer patients requires a sensitive and personalized approach.

Dr.Camel's Conclusion

This study, like a cool spring in the desert, offers relief to those battling prostate cancer. It provides valuable insights into the effectiveness of strontium-89 for managing bone pain, potentially offering a more tolerable option compared to chemotherapy.

Date :
  1. Date Completed 2005-06-24
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

15857738

DOI: Digital Object Identifier

10.1016/j.jpainsymman.2004.07.008

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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