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Neoadjuvant percutaneous 4-hydroxytamoxifen decreases breast tumoral cell proliferation: a prospective controlled randomized study comparing three doses of 4-hydroxytamoxifen gel to oral tamoxifen.

Author: DravetFrançois, GiraultJean, GourgouSophie, GrenierJean, KramarAndrew, Le NestourElisabeth, Linares-CruzGustavo, MaudelondeThierry, PoujolSylvain, RouanetPhilippe, Simony-LafontaineJoelle

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This randomized study evaluated the efficacy of percutaneously administered 4-hydroxytamoxifen (4-OHT) gel in inhibiting breast cancer cell proliferation compared to oral tamoxifen.
Paper Details　
Original Abstract of the Article :
Two chemoprevention randomized studies using tamoxifen showed drug efficacy; however, adverse effects such as hot flushes, endometrial cancer, and above all, thromboembolism, remain a problem. 4 hydroxytamoxifen (4-OHT) is a very active metabolite of tamoxifen. This randomized study was designed to ...See full text at original site
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引用元：
https://doi.org/10.1200/JCO.2005.06.064

データ提供：米国国立医学図書館（NLM）

Neoadjuvant Tamoxifen: A Targeted Approach to Breast Cancer

Breast cancer is a complex disease, and researchers are continually seeking new and effective ways to prevent and treat it. This study explores the potential of a novel treatment approach, neoadjuvant percutaneous 4-hydroxytamoxifen, to reduce breast tumor cell proliferation. The researchers, like skilled surgeons, sought to find a targeted and minimally invasive way to shrink tumors before surgery.

4-Hydroxytamoxifen Gel: A Promising New Approach to Breast Cancer Treatment

This study investigated the effects of percutaneous 4-hydroxytamoxifen gel, applied directly to the breast skin, on breast tumor cell proliferation. The researchers discovered that this treatment, like a targeted laser, effectively reduced tumor cell proliferation. They found that the gel was as effective as oral tamoxifen, but potentially with fewer side effects, suggesting that this novel approach could be a valuable tool in the fight against breast cancer.

Minimally Invasive Therapies: A New Frontier in Breast Cancer Treatment

This study highlights the potential of minimally invasive therapies for treating breast cancer. It's like a skilled surgeon using a scalpel with precision and care. This approach offers a potentially less invasive and more tolerable option for patients, while maintaining the effectiveness of traditional therapies.

Dr.Camel's Conclusion

This research offers a promising new direction for treating breast cancer. It's like discovering a new oasis in the vast desert of breast cancer treatment options. The findings suggest that neoadjuvant percutaneous 4-hydroxytamoxifen gel may be an effective and potentially less invasive approach to reducing tumor cell proliferation. This study represents a significant step towards more personalized and less disruptive treatments for breast cancer.

Date :
  1. Date Completed 2005-06-03
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15860853

DOI: Digital Object Identifier

10.1200/JCO.2005.06.064

Related Literature

Article Analysis
・Effects of tamoxifen
SNS
PICO Info
in preparation
Languages

English

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