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Analyses of treatment-emergent mania with olanzapine/fluoxetine combination in the treatment of bipolar depression.

Author: AltshulerLori L, BriggsSusan D, CaseMichael, CoryaSara A, KeckPaul E, KetterTerence A, McElroySusan L, TohenMauricio

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Olanzapine/fluoxetine combination did not present a greater risk of treatment-emergent mania compared to olanzapine or placebo over 8 weeks of acute treatment for bipolar I depression.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Treatment-emergent mania is a potential risk when patients with bipolar disorder are treated with antidepressant agents. These subanalyses compare treatment-emergent mania rates in bipolar I depressed patients treated with olanzapine, placebo, or olanzapine/fluoxetine combination. METHO...See full text at original site
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引用元：
https://doi.org/10.4088/jcp.v66n0511

データ提供：米国国立医学図書館（NLM）

Olanzapine/Fluoxetine Combination for Bipolar Depression: A Quest for Balance

The treatment of bipolar disorder is a delicate balancing act, much like navigating a shifting sand dune. This research explores the use of the olanzapine/fluoxetine combination as a treatment for bipolar depression, paying close attention to the potential risk of treatment-emergent mania. The researchers conducted an eight-week double-blind investigation with 833 patients, comparing the effects of olanzapine, placebo, and the olanzapine/fluoxetine combination on the incidence of treatment-emergent mania. The findings revealed that the olanzapine/fluoxetine combination did not demonstrate a greater risk of treatment-emergent mania compared to olanzapine or placebo.

Olanzapine/Fluoxetine Combination: A Potential Treatment for Bipolar Depression

The study found that patients receiving olanzapine or the olanzapine/fluoxetine combination experienced greater decreases in mania symptoms compared to those receiving placebo. However, due to the cyclical nature of bipolar disorder, close monitoring for signs of emerging mania is still recommended for patients taking the olanzapine/fluoxetine combination.

Navigating the Desert of Bipolar Disorder

This research adds to our understanding of the treatment of bipolar depression, emphasizing the importance of balancing mood stabilization and symptom reduction. It is a reminder that effective treatment requires a multifaceted approach, taking into account individual patient needs and the complex nature of this mental health condition.

Dr.Camel's Conclusion

This research provides valuable insights into the safety and efficacy of the olanzapine/fluoxetine combination for the treatment of bipolar depression. It underscores the importance of ongoing monitoring and individualised treatment approaches for this challenging condition.

Date :
  1. Date Completed 2005-07-11
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

15889948

DOI: Digital Object Identifier

10.4088/jcp.v66n0511

Related Literature

Article Analysis
・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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