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Colonic targeting of aminosalicylates for the treatment of ulcerative colitis.

Author: KlotzU

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article reviewed the use of aminosalicylates (5-aminosalicylic acid) for the treatment of ulcerative colitis. Aminosalicylates are the drugs of first choice for this condition, and they can be delivered to the colon via inactive azo-prodrugs or special galenic formulations. The article discussed the different therapeutic approaches and their efficacy and side effects.
Paper Details　
Original Abstract of the Article :
Aminosalicylates (5-aminosalicylic acid) represent drugs of first choice in the treatment of ulcerative colitis. Two different therapeutic approaches have been employed to target the active 5-aminosalicylic acid to its site of action. Either inactive azo-prodrugs (e.g. sulfasalazine, olsalazine, bal...See full text at original site
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引用元：
https://doi.org/10.1016/j.dld.2004.12.011

データ提供：米国国立医学図書館（NLM）

Targeting Aminosalicylates: A Journey to the Colon

Ulcerative colitis, an inflammatory bowel disease, is like a relentless sandstorm in the digestive tract. It causes inflammation, ulcers, and discomfort. Aminosalicylates (5-aminosalicylic acid) are common medications used to treat ulcerative colitis, but delivering them to the right spot in the colon can be tricky. Think of it like trying to transport water to a specific oasis in a vast desert. This study explores different ways to target aminosalicylates to the colon, where they can work their magic.

Aminosalicylates: Finding the Path to Healing

The study explores two approaches: using inactive azo-prodrugs that break down into active 5-aminosalicylic acid in the colon and using special galenic formulations designed for topical delivery. While both methods have shown some success, they haven't consistently led to complete remission for all patients. This variability in effectiveness is like the different routes through a desert – some are easier to navigate than others. The researchers emphasize the importance of achieving high local concentrations of 5-aminosalicylic acid in the colon to achieve optimal therapeutic effects. It's like ensuring the oasis receives enough water to flourish.

Navigating Ulcerative Colitis: A Guide Through the Desert

If you're struggling with ulcerative colitis, it's important to work closely with your doctor to find the right treatment. They can assess your individual needs and recommend the best approach for you. Remember, managing ulcerative colitis is like navigating a difficult desert. With the right guidance and support, you can find your way to a healthier and more comfortable life.

Dr.Camel's Conclusion

This study underscores the importance of finding effective ways to deliver aminosalicylates to the colon for optimal treatment of ulcerative colitis. It's like searching for the right path through a desert, hoping to reach a lush oasis of relief.

Date :
  1. Date Completed 2005-10-18
  2. Date Revised 2006-11-15
Further Info :

Pubmed ID

15893274

DOI: Digital Object Identifier

10.1016/j.dld.2004.12.011

SNS
PICO Info
in preparation
Languages

English

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