Combined oral and enema treatment with Pentasa (mesalazine) is superior to oral therapy alone in patients with extensive mild/moderate active ulcerative colitis: a randomised, double blind, placebo controlled study.

Author: BefritsR, DignassA, FoldagerM, GassulM, LindgrenS, MarteauP, MidhagenG, ProbertC S, RademakerJ, TanT G

Paper Details 
Original Abstract of the Article :
Oral aminosalicylates are well established in the treatment of active mild/moderate ulcerative colitis (UC) when the disease is extensive (that is, beyond the splenic flexure). The majority of clinical symptoms relate to disease activity in the distal part of the colon and therefore this study was d...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774619/

データ提供:米国国立医学図書館(NLM)

Ulcerative Colitis: Finding the Right Oasis in the Desert of Treatment

Ulcerative colitis (UC), a chronic inflammatory bowel disease, can feel like a vast desert of symptoms and challenges for patients. This study, like a caravan searching for the most effective route, explores the potential benefits of combining oral and enema treatment with mesalazine, a commonly used medication for UC, in patients with extensive mild/moderate active UC. The study enrolled patients and randomly assigned them to receive either oral mesalazine alone or a combination of oral and enema mesalazine. The researchers found that the combined treatment resulted in superior outcomes, highlighting the potential for this approach to offer a more effective solution for patients with extensive UC.

Finding a More Effective Oasis: Combined Treatment Shows Promise for UC

The findings of this study, like a refreshing oasis in the desert of UC treatment, suggest that combining oral and enema mesalazine may provide a more effective strategy for managing extensive UC. The superior outcomes observed in the combined treatment group underscore the importance of tailoring treatment approaches to the specific needs of each patient, aiming to target inflammation in the affected areas of the colon.

Navigating the Desert of UC: Seeking the Right Approach

The desert of UC management requires a collaborative approach between patients and healthcare providers. This research highlights the importance of exploring different treatment options and tailoring them to individual needs. With careful monitoring and open communication, patients can work with their doctors to find the most effective oasis of relief and improve their quality of life.

Dr. Camel's Conclusion

This study, like a camel caravan finding a new, more effective route through the desert of UC, offers valuable insights into the potential benefits of combined oral and enema mesalazine treatment. The superior outcomes observed in this approach suggest that personalized treatment strategies can lead to better outcomes for patients with extensive UC. As we continue to explore this complex desert, we can embrace new approaches that offer hope for a more manageable and fulfilling life for those affected by this chronic condition.

Date :
  1. Date Completed 2005-08-08
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

15951542

DOI: Digital Object Identifier

PMC1774619

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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