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Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS.

Author: FergusonBrandy, FiermonteGiuseppe, HaaseChad P, LewisWilliam, LongRobert, LudawayTomika, McNaughtJamie, MillerYoon K, PalmieriFerdinando, RussRodney, SantoianniRobert, SteltzerJeffrey, StuartTami

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Nucleoside reverse transcriptase inhibitors (NRTIs) are drugs used to treat AIDS. However, NRTIs can cause mitochondrial side effects. Studies show that transgenic mice that overexpress the mitochondrial deoxynucleotide carrier (DNC) in the heart are more susceptible to cardiac dysfunction when treated with NRTIs. This suggests that the DNC may play a role in mitochondrial dysfunction in patients treated with NRTIs.
Paper Details　
Original Abstract of the Article :
Nucleoside reverse transcriptase inhibitors (NRTIs) are antiretrovirals for AIDS with limiting mitochondrial side effects. The mitochondrial deoxynucleotide carrier (DNC) transports phosphorylated nucleosides for mitochondrial DNA replication and can transport phosphorylated NRTIs into mitochondria....See full text at original site
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引用元：
https://doi.org/10.1038/labinvest.3700301

データ提供：米国国立医学図書館（NLM）

Investigating the Role of Deoxynucleotide Carrier in Mitochondrial Dysfunction from NRTIs

This study delves into the complex world of mitochondrial dysfunction, specifically investigating the role of the deoxynucleotide carrier (DNC) in the adverse effects of nucleoside reverse transcriptase inhibitors (NRTIs), a class of antiretroviral drugs used to treat HIV/AIDS. The researchers used transgenic mice to model the effects of DNC overexpression on mitochondrial function in the context of NRTI therapy.

Unraveling the Mechanisms of NRTI-Induced Mitochondrial Dysfunction

The study revealed that overexpression of DNC, a key protein involved in mitochondrial DNA replication, led to mitochondrial damage and enhanced the adverse effects of NRTIs on heart function. This finding suggests that DNC may play a crucial role in the development of mitochondrial toxicity associated with NRTI therapy. The study underscores the importance of understanding the complex interplay between drugs, cellular targets, and mitochondrial function.

Understanding the Risks and Benefits of Antiretroviral Therapy

This research provides valuable insights into the potential risks and benefits of antiretroviral therapy for HIV/AIDS. The study's findings highlight the importance of considering the potential impact of NRTIs on mitochondrial function and developing strategies to mitigate these adverse effects. This research emphasizes the need for a comprehensive understanding of the complex interplay between drugs, cellular targets, and overall health outcomes.

Dr. Camel's Conclusion

This research takes us on a journey into the intricate world of mitochondrial function and the potential impact of antiretroviral therapy on cellular health. The study's findings highlight the complex interplay between drugs, cellular targets, and mitochondrial function, underscoring the importance of ongoing research to develop safer and more effective treatments for HIV/AIDS. Just as a camel adapts to the changing landscapes of the desert, we must continually adapt our understanding of drug therapy, ensuring that we provide the best possible care for our patients while minimizing potential risks.

Date :
  1. Date Completed 2005-10-31
  2. Date Revised 2023-02-16
Further Info :

Pubmed ID

15951836

DOI: Digital Object Identifier

10.1038/labinvest.3700301

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