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Recent advances in antidepressant drugs.

Author: BaldwinD S, BullockT, KibelD, PriestR G, SmeyatskyN, SteinertJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Moclobemide, a reversible inhibitor of monoamine oxidase A (RIMA), is a safe and effective antidepressant with a low incidence of side effects. It offers a potential alternative to tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs), which have more drawbacks.
Paper Details　
Original Abstract of the Article :
Tricyclic antidepressants (TCAs) are notorious for a number of disadvantages, but particularly for an array of side-effects that leads to poor compliance, and also for a dangerous toxicity in overdose. Lofepramine is a new tricyclic that seems safer. Selective serotonin reuptake inhibitors (SSRIs) a...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1609337

データ提供：米国国立医学図書館（NLM）

Antidepressants: A Journey Through Different Approaches

The search for effective treatments for depression has led to the development of a wide range of antidepressants, each with its own unique mechanisms of action and side-effect profiles. This review examines the evolution of antidepressant drugs, highlighting their strengths and limitations.

From Tricyclics to SSRIs and Beyond

The review traces the development of antidepressants from the older tricyclic antidepressants (TCAs) to the more selective serotonin reuptake inhibitors (SSRIs) and reversible inhibitors of monoamine oxidase A (RIMAs). The advent of SSRIs has been marked by an improvement in the side-effect profile, while RIMAs, such as moclobemide, have proven to be remarkably safe and effective for severe depression.

Tailoring Treatment to Individual Needs

The choice of antidepressant medication is a complex decision that requires careful consideration of the patient's individual needs and medical history. It's like navigating a desert with different paths available – some paths may be more direct, while others may be more suitable for certain travelers.

Dr.Camel's Conclusion

This review highlights the ongoing evolution of antidepressant medications, offering hope for individuals struggling with depression. As our understanding of the neurobiological mechanisms of depression continues to grow, we can expect to see even more effective and targeted therapies emerge in the future.

Date :
  1. Date Completed 1992-07-21
  2. Date Revised 2014-09-12
Further Info :

Pubmed ID

1609337

DOI: Digital Object Identifier

1609337

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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