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Midazolam in combination with propofol for sedation during local anesthesia.

Author: GhouriA F, TaylorE, WhiteP F

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Midazolam 2 mg IV administered prior to propofol infusion produced increased sedation, amnesia, and anxiolysis for outpatient surgery.
Paper Details　
Original Abstract of the Article :
STUDY OBJECTIVE: To compare the sedative, anxiolytic, and amnestic effects, as well as the recovery characteristics, when midazolam (vs. a placebo) is administered to patients receiving a propofol infusion for sedation during local anesthesia. DESIGN: Randomized, double-blind, placebo-controlled st...See full text at original site
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引用元：
https://doi.org/10.1016/0952-8180(92)90068-c

データ提供：米国国立医学図書館（NLM）

Midazolam and Propofol: A Synergistic Approach to Sedation

Surgery, like a journey through the desert, can be a daunting experience for many patients. This study explores the potential of combining midazolam, an anxiolytic drug, with propofol, a sedative, to enhance sedation during local anesthesia. The study employed a randomized, double-blind, placebo-controlled design to compare the sedative, anxiolytic, and amnestic effects of midazolam when combined with propofol, compared to propofol alone. The research aimed to evaluate the effectiveness of this drug combination in reducing anxiety, enhancing sedation, and improving patient recall of intraoperative events.

A Smooth Journey Through the Desert

The study found that midazolam, when administered prior to propofol infusion, significantly increased sedation, reduced anxiety, and improved amnesia in patients undergoing surgery under local anesthesia. The combination of midazolam and propofol resulted in greater sedation and anxiety relief compared to propofol alone. This suggests that combining these drugs may provide a more effective and comfortable sedation experience for patients undergoing surgical procedures. It's like finding a smooth, well-paved road through the desert, making the journey more comfortable and enjoyable.

Navigating the Shifting Sands of Sedation

This study offers valuable insights into the complexities of sedation management during surgical procedures. It underscores the importance of considering the individual needs of patients and exploring different drug combinations to optimize sedation and minimize anxiety. It’s a reminder that the desert of sedation is constantly shifting, and we must constantly seek new approaches to improve patient comfort and care during medical procedures.

Dr. Camel's Conclusion

Combining midazolam with propofol offers a potential solution for enhancing sedation and minimizing anxiety during surgical procedures. The study’s findings demonstrate the potential benefits of this drug combination, highlighting the importance of careful consideration of sedation options to ensure the best possible patient experience.

Date :
  1. Date Completed 1992-07-30
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

1610577

DOI: Digital Object Identifier

10.1016/0952-8180(92)90068-c

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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