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Demographic, environmental, and genetic predictors of metabolic side effects of hydrochlorothiazide treatment in hypertensive subjects.

Author: BoerwinkleEric, ChapmanArlene B, KlungelOlaf H, Maitland-van der ZeeAnke-Hilse, SchwartzGary L, TurnerStephen T

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigates the variability in glucose and lipid responses to hydrochlorothiazide, a thiazide diuretic commonly used for hypertension. The study aims to identify demographic, environmental, and genetic factors associated with this variability.
Paper Details　
Original Abstract of the Article :
Thiazide diuretics are recommended for first-line treatment of hypertension. Although considered safe and effective, their use is associated with dyslipidemia, hyperglycemia, and an increased risk of developing type 2 diabetes. The aim of this study was to characterize interindividual variation in g...See full text at original site
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引用元：
https://doi.org/10.1016/j.amjhyper.2005.02.012

データ提供：米国国立医学図書館（NLM）

Hydrochlorothiazide and Metabolic Side Effects: Exploring the Desert of Individual Variation

Hydrochlorothiazide, a common medication for hypertension, is a reliable companion in the fight against high blood pressure. However, like many medications, it can sometimes have unexpected side effects. This study delves into the world of individual variation in metabolic responses to hydrochlorothiazide, exploring factors that influence the development of dyslipidemia, hyperglycemia, and increased risk of type 2 diabetes.

The Influence of Individual Variation on Hydrochlorothiazide Response

This study underscores the importance of considering individual factors when prescribing hydrochlorothiazide. Researchers identified demographic, environmental, and genetic predictors associated with varying metabolic responses to the medication. These findings emphasize the need for personalized approaches to medication management, tailoring treatment to individual needs and minimizing the risk of adverse metabolic effects.

Navigating the Desert of Personalized Medicine

This study serves as a reminder that the desert of personalized medicine is vast and complex. Understanding individual variations in drug response is crucial for optimizing treatment outcomes and minimizing potential risks. Continued research into the factors influencing drug response will help us navigate this desert and provide more personalized and effective healthcare solutions.

Dr. Camel's Conclusion

This study highlights the importance of individual factors in influencing metabolic responses to hydrochlorothiazide, emphasizing the need for personalized approaches to medication management. The journey through the desert of personalized medicine continues, requiring ongoing research to develop more tailored and effective treatment strategies.

Date :
  1. Date Completed 2005-11-29
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

16109321

DOI: Digital Object Identifier

10.1016/j.amjhyper.2005.02.012

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・Side Effects of hydrochlorothiazide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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