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Transmission of hepatitis C virus among HIV-positive homosexual men and response to a 24-week course of pegylated interferon and ribavirin.

Author: AsboeDavid, AtkinsMark, BowerMark, BrowneRita E, GazzardBrian G, GilleeceYvonne C, MandaliaSundhiya, NelsonMark R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Sustained virologic response rates for acute hepatitis C virus (HCV) treatment were lower in HIV-positive patients compared to HIV-negative subjects. Spontaneous seroconversion was common, so treatment should be delayed until after 12 weeks.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate treatment outcome of acute hepatitis C virus (HCV) in HIV-positive individuals. DESIGN: Open-label, prospective study conducted in London, January 1997-December 2003. METHODS: Patients in whom acute HCV infection had been diagnosed had sequential HCV RNA levels measured at 0...See full text at original site
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引用元：
https://doi.org/10.1097/01.qai.0000174930.64145.a9

データ提供：米国国立医学図書館（NLM）

Treating Hepatitis C in HIV-Positive Individuals: A Complex Challenge

Greetings, fellow researchers! Dr. Camel here, venturing into the complex world of co-infection, exploring the challenges of treating hepatitis C in individuals with HIV. This research examines the treatment outcomes of acute hepatitis C virus (HCV) infection in HIV-positive homosexual men, highlighting the unique challenges presented by this patient population. It's like navigating a double desert, battling two formidable foes simultaneously.

Challenges and Treatment Outcomes

The study reveals that sustained virologic response rates in HIV-positive patients treated for acute HCV infection are lower compared to their HIV-negative counterparts. It's a tough battle in a harsh desert environment, demanding a more nuanced and focused approach. The research also highlights the importance of baseline CD4+ count and HCV RNA titers in predicting treatment response. These factors act like guideposts in a vast desert, helping to navigate the complexities of this co-infection.

The Role of Early Detection and Treatment

The study suggests that treatment should be delayed until after 12 weeks of infection, allowing for the possibility of spontaneous clearance. It's a strategic approach, like carefully observing the desert landscape before embarking on a journey. This research underscores the importance of early detection and individualized treatment strategies for HIV-positive individuals with HCV infection.

Dr. Camel's Conclusion

This research offers valuable insights into the challenges of treating HCV infection in HIV-positive individuals. It highlights the need for tailored treatment approaches and the importance of factors such as baseline CD4+ count and HCV RNA titers in predicting treatment outcomes. It's a journey through the complex desert of co-infection, where knowledge and understanding are essential for navigating the challenges and providing effective care.

Date :
  1. Date Completed 2005-11-02
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

16123680

DOI: Digital Object Identifier

10.1097/01.qai.0000174930.64145.a9

Related Literature

Article Analysis
・Effective treatment of hepatitis c
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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