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Dose-dependent aspirin hydrolysis and platelet aggregation in patients with atherosclerosis.
Author: AkopovS S, GabrielianE S, GrigorianG S
Original Abstract of the Article :
In a double blind, randomized trial, the effects of aspirin (1, 5, and 15 mg/kg) were compared with the changes in platelet aggregation at 6 and 24 hours after dosage. It is found that there is a negative correlation between aspirin hydrolysis velocity in blood and capability of aspirin to decrease ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1002/j.1552-4604.1992.tb03817.x
データ提供:米国国立医学図書館(NLM)
Aspirin's Impact on Platelet Aggregation
This study explores the relationship between aspirin dosage, aspirin hydrolysis, and platelet aggregation in patients with atherosclerosis. It's like examining the intricate ecosystem of a desert, where even subtle changes in the environment can have significant effects. The study found that the effectiveness of aspirin in reducing platelet aggregation varied depending on the dosage and the rate of aspirin hydrolysis. This finding is important for understanding the optimal dosage of aspirin for patients with atherosclerosis.
The Importance of Personalized Aspirin Therapy
This study highlights the need for personalized aspirin therapy. It's like adapting to the specific conditions of a desert region to ensure survival. Just as a camel adapts to the arid environment, patients require individualized treatment plans to achieve optimal results. The study suggests that the effectiveness of aspirin therapy may depend on the individual's metabolism and other factors.
Aspirin Therapy: A Balancing Act
Aspirin is a common medication, but this study emphasizes the importance of understanding its dosage and how it interacts with the body. It's a reminder that even seemingly simple medications can have complex effects. This study provides valuable insights into the nuances of aspirin therapy and underscores the importance of monitoring and adjusting treatment plans as needed.
Dr.Camel's Conclusion
This study teaches us that even a seemingly simple medication like aspirin can have a complex interplay with the body. It's a reminder that in the vast desert of medical knowledge, we must always strive to understand the nuances and complexities of each treatment and how it interacts with our individual biology.
Date :
- Date Completed 1992-07-30
- Date Revised 2019-08-24
Further Info :
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English
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