Dose-dependent aspirin hydrolysis and platelet aggregation in patients with atherosclerosis.

Author: AkopovS S, GabrielianE S, GrigorianG S

Paper Details 
Original Abstract of the Article :
In a double blind, randomized trial, the effects of aspirin (1, 5, and 15 mg/kg) were compared with the changes in platelet aggregation at 6 and 24 hours after dosage. It is found that there is a negative correlation between aspirin hydrolysis velocity in blood and capability of aspirin to decrease ...See full text at original site
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引用元:
https://doi.org/10.1002/j.1552-4604.1992.tb03817.x

データ提供:米国国立医学図書館(NLM)

Aspirin's Impact on Platelet Aggregation

This study explores the relationship between aspirin dosage, aspirin hydrolysis, and platelet aggregation in patients with atherosclerosis. It's like examining the intricate ecosystem of a desert, where even subtle changes in the environment can have significant effects. The study found that the effectiveness of aspirin in reducing platelet aggregation varied depending on the dosage and the rate of aspirin hydrolysis. This finding is important for understanding the optimal dosage of aspirin for patients with atherosclerosis.

The Importance of Personalized Aspirin Therapy

This study highlights the need for personalized aspirin therapy. It's like adapting to the specific conditions of a desert region to ensure survival. Just as a camel adapts to the arid environment, patients require individualized treatment plans to achieve optimal results. The study suggests that the effectiveness of aspirin therapy may depend on the individual's metabolism and other factors.

Aspirin Therapy: A Balancing Act

Aspirin is a common medication, but this study emphasizes the importance of understanding its dosage and how it interacts with the body. It's a reminder that even seemingly simple medications can have complex effects. This study provides valuable insights into the nuances of aspirin therapy and underscores the importance of monitoring and adjusting treatment plans as needed.

Dr.Camel's Conclusion

This study teaches us that even a seemingly simple medication like aspirin can have a complex interplay with the body. It's a reminder that in the vast desert of medical knowledge, we must always strive to understand the nuances and complexities of each treatment and how it interacts with our individual biology.

Date :
  1. Date Completed 1992-07-30
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

1613122

DOI: Digital Object Identifier

10.1002/j.1552-4604.1992.tb03817.x

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Languages

English

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