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Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids.

Author: ColemanM, ElSohlyM A, GevinsA, IlanA B, de WitH

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study found that THC and its metabolites are the primary active constituents of marijuana, and that neurophysiological EEG and ERP measures are useful biomarkers for its effects, while varying the concentrations of CBC and CBD had no significant impact on subjective, behavioral, or neurophysiological responses.
Paper Details　
Original Abstract of the Article :
This study investigated the contribution of different cannabinoids to the subjective, behavioral and neurophysiological effects of smoked marijuana. Healthy marijuana users (12 men, 11 women) participated in four sessions. They were randomly assigned to a low or a high delta9-tetrahydrocannabinol gr...See full text at original site
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引用元：
https://doi.org/10.1097/00008877-200509000-00023

データ提供：米国国立医学図書館（NLM）

Exploring the Neurophysiological Effects of Marijuana

This study dives into the fascinating world of marijuana, exploring the impact of various cannabinoids on our brains and behavior. It's like studying a vast desert, with different areas holding unique secrets. They used a clever approach, like an ancient explorer mapping out a new land, by comparing the effects of marijuana with different concentrations of THC, CBC, and CBD. The researchers used a group of healthy marijuana users, similar to a caravan of seasoned travelers navigating through the desert, to analyze the effects on mood, cognition, and brain activity. They found that THC was the primary active ingredient, influencing brain activity and cognitive performance. This is like a key ingredient in a spice mix, adding unique flavors to the overall experience. The study also suggested that brainwave patterns, like the rhythmic echoes in a desert canyon, could be useful biomarkers for the effects of THC.

THC's Influence on Cognitive Performance

The findings of this study suggest that THC, like a mirage in the desert, can affect our ability to focus and process information. They observed a decline in performance on tests of working memory and episodic memory, which is like losing your way in a sandstorm. These effects weren't always directly related to the dose, indicating that THC's impact can be unpredictable, like the ever-shifting sands of the desert.

The Role of Other Cannabinoids

The researchers found that varying the levels of CBC and CBD didn't significantly change the participants' responses. This suggests that these cannabinoids might not be the primary drivers of marijuana's effects, similar to the silent presence of other plants in a desert ecosystem. It's a reminder that the complex world of marijuana is still being explored, with many secrets yet to be uncovered.

Dr. Camel's Conclusion

This study provides valuable insights into the complex effects of marijuana, emphasizing the importance of THC in shaping the experience. It's a reminder that the desert of knowledge surrounding marijuana is vast, and every new study provides a grain of sand to our understanding of this fascinating plant.

Date :
  1. Date Completed 2006-01-09
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

16148455

DOI: Digital Object Identifier

10.1097/00008877-200509000-00023

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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