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Effect of mitoxantrone on MRI in progressive MS: results of the MIMS trial.

Author: , GonsetteR, HartungH-P, KrapfH, MorrisseyS P, ZenkerO, ZwingersT

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Mitoxantrone (Mx) did not significantly reduce the number of MRI scans with positive Gd enhancement at 12 and 24 months compared to placebo in patients with progressive multiple sclerosis (MS). However, secondary MRI outcome measures suggested a positive impact of Mx on some of the Gd-enhanced and unenhanced MRI measures.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the effects of mitoxantrone (Mx) in progressive multiple sclerosis (MS) on MRI. METHODS: A total of 194 patients with worsening relapsing-remitting or secondary progressive MS were treated with Mx 12 mg/m2 (n = 34), Mx 5 mg/m2 (n = 40), or placebo (n = 36) at 3-month interval...See full text at original site
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引用元：
https://doi.org/10.1212/01.wnl.0000174439.70369.7a

データ提供：米国国立医学図書館（NLM）

Mitoxantrone: A Potential Oasis in the Desert of Progressive MS

Multiple sclerosis (MS) is a challenging neurological disease, and researchers are constantly searching for effective treatments. This study explores the effects of mitoxantrone (Mx) on magnetic resonance imaging (MRI) in patients with progressive MS. The researchers conducted a clinical trial, comparing the effects of Mx at two different dosages to placebo. The study found that Mx had some positive effects on certain MRI measures, but it did not significantly reduce the number of MRI scans with positive gadolinium enhancement, which is a marker of disease activity.

Navigating the Complexity of Progressive MS Treatment

This research highlights the complex nature of progressive MS treatment. While Mx may have some positive effects, further research is needed to fully understand its role in managing this challenging neurological disease. The study's findings underscore the need for continued exploration of new treatment options for progressive MS.

Hope for Future Research and Treatment Strategies

The study's results provide valuable insights into the potential benefits and limitations of Mx in the treatment of progressive MS. Continued research is crucial to develop more effective therapies and improve the lives of individuals with this debilitating disease. The journey through the desert of MS research continues, and we, as researchers, are dedicated to finding new oases of hope for patients.

Dr. Camel's Conclusion

This study offers valuable insights into the potential benefits and limitations of mitoxantrone in treating progressive MS. While the results suggest some positive effects on certain MRI measures, further research is needed to optimize its use and develop more effective therapies for this challenging disease. We, as researchers, continue our trek through the desert of MS research, seeking solutions that improve the lives of individuals with this debilitating condition.

Date :
  1. Date Completed 2005-11-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16157900

DOI: Digital Object Identifier

10.1212/01.wnl.0000174439.70369.7a

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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