Effective treatment of multiple sclerosis: A Synthesis of Findings from 43 Studies

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Original Abstract of the Article

Main Research Findings

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. Various approaches are used to treat MS, including drug therapy, physical therapy, and lifestyle modifications. Recent studies have shown that these approaches can be effective in improving MS symptoms and slowing disease progression. shows that drug therapy, specifically called immunomodulators, can help reduce MS symptoms and slow disease progression. demonstrates that physical therapy helps improve muscle stiffness and walking difficulties caused by MS. suggests that lifestyle modifications, such as stress management and moderate exercise, can help reduce MS symptoms and improve quality of life. These studies suggest that combining various approaches is crucial for treating MS.

Benefits and Risks

Benefits Summary

MS treatment involves various approaches, including drug therapy, physical therapy, and lifestyle modifications. Recent studies have shown that these approaches can be effective in improving MS symptoms and slowing disease progression. shows that drug therapy, specifically called immunomodulators, can help reduce MS symptoms and slow disease progression. demonstrates that physical therapy helps improve muscle stiffness and walking difficulties caused by MS. suggests that lifestyle modifications, such as stress management and moderate exercise, can help reduce MS symptoms and improve quality of life. These studies suggest that combining various approaches is crucial for treating MS.

Risks Summary

Treating MS may involve risks of side effects. Drug therapy can lead to various side effects, including nausea, abdominal pain, rash, and an increased risk of infections. Physical therapy may rarely cause side effects such as pain or muscle injury. Lifestyle modifications may be difficult to implement for individuals who struggle with exercise or experience high levels of stress. It is essential to consult with a physician and choose appropriate treatments to minimize these risks.

Comparison Between Studies

Similarities in Studies

Multiple studies have shown that various approaches, including drug therapy, physical therapy, and lifestyle modifications, can be helpful in treating MS. These approaches are often used in combination to reduce MS symptoms and slow disease progression.

Differences in Studies

Different studies have yielded varying results regarding the effectiveness of specific approaches for treating MS. While some studies showed specific drug therapies or physical therapies to be effective, others did not observe significant effects. Additionally, participant characteristics and study designs varied across studies, making it challenging to compare results.

Consistency and Contradictions in Results

Research findings on treating MS exhibit both consistency and contradictions. Some studies have shown specific drug therapies or physical therapies to be effective. However, other studies have indicated that these approaches do not yield significant results. These contradictions may be attributed to differences in methodologies and participant characteristics across studies.

Practical Implications and Considerations

Consulting a physician and choosing appropriate treatments is crucial to manage MS symptoms. Various approaches, including drug therapy, physical therapy, and lifestyle modifications, may be helpful. However, these approaches are not effective for everyone. Additionally, there are risks of side effects, so it is essential to follow physician guidance and implement them carefully.

Limitations of Current Research

There are limitations to research on treating MS. Many studies have been conducted with small sample sizes, making it difficult to generalize results. Additionally, many studies have focused on specific types of MS, making it challenging to apply results to other types of MS.

Future Research Directions

Further research is needed on treating MS. Specifically, studies with larger sample sizes and involving various types of MS are required. Research is also needed on the long-term effects of specific approaches in treating MS.

Conclusion

MS is a chronic autoimmune disease that affects many people worldwide. Various approaches are used to treat MS, including drug therapy, physical therapy, and lifestyle modifications. These approaches are often used in combination to reduce MS symptoms and slow disease progression. However, there are limitations to research on treating MS, and further research is needed. If you have MS symptoms, it is crucial to consult with a physician and choose appropriate treatments.

Keywords
Benefit Keywords
Enhanced quality of life
Improved motor function
Improved quality of life
Reduced disability
1
Reduced MRI lesions
2
Improved neurological function
7
Cognitive processing speed improvement
9
MS treatment
Reduces cognitive symptoms
10
Safe treatment
11
Treatment effects
12
Improved MS management
MS treatment
Reduced relapse and disability
13
Improved cognitive deficits
14
Reduced relapse rate
Slowed disability progression
15
Improved MS symptoms
16
Cognitive rehabilitation
Neuropsychological rehabilitation
17
Inflammation reduction
Tissue damage reduction
18
Cognitive intervention
19
Minimized physical impact
20
Improved MS quality of life
MS treatment
Potential for non-pharmacological interventions
23
Improved gait
26
Assessment of MS lesion acuity
27
Cognitive management
Improved MS management
MS treatment
28
Slowed MS progression
29
Reduced depression
30
bladder dysfunction reduction
pain reduction
spasticity reduction
31
MS remyelination
32
MS biomarker improvement
33
DMTs
Improved MS management
MS treatment
34
Balance
Fatigue
Functionality
Quality of life
35
Diet
36
Improved MS treatment
37
Gray matter atrophy
38
Balance improvement
Coordination improvement
Dexterity improvement
Emotional status improvement
Fatigue reduction
Gait improvement
Pain reduction
Strength improvement
Walking endurance improvement
39
Depressive symptom improvement
HRQoL improvement
40
Increased QoL
Non-pharmacological interventions
42
Decreased disease activity
MS treatment
43
Risk Keywords
Limited impact on severe MS
Requires ongoing interventions
Temporary effects
1
Nocebo effect
4
None
10
Ineffective for MS
11
Needs further research
Unclear optimal therapy
13
Multiple sclerosis
15
Multiple sclerosis
17
Cognitive impairments
Multiple Sclerosis
19
Disability progression
21
Regression to the mean
22
Limited pharmacological effectiveness
Needs further research
23
Multiple sclerosis
26
Limited treatment options
Needs further research
28
Adverse psychiatric effects
30
adverse effects
31
MS treatment
32
MS exercise
33
Needs further research
Unclear optimal therapy
34
New lesions
38
Post-marketing side effects of DMDs for MS
41
MS
42
Safety uncertainty
Significant disability
43
Literature analysis of 43 papers
Positive Content
36
Neutral Content
3
Negative Content
4
Article Type
15
22
21
16
43
2.

Effect of mitoxantrone on MRI in progressive MS: results of the MIMS trial.

Author: KrapfH, MorrisseyS P, ZenkerO, ZwingersT, GonsetteR, HartungH-P,

Reduced MRI lesions

Mitoxantrone (Mx) did not significantly reduce the number of MRI scans with positive Gd enhancement at 12 and 24 months compared to placebo in patients with progressive multiple sclerosis (MS). However, secondary MRI outcome measures suggested a positive impact of Mx on some of the Gd-enhanced and unenhanced MRI measures.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effects of rivastigmine on memory and cognition in multiple sclerosis.

Author: ShaygannejadVahid, JanghorbaniMohsen, AshtariFereshteh, ZanjaniHamid Afshar, ZakizadeNaser

Rivastigmine did not show significant differences compared to placebo in improving memory and cognitive function in patients with multiple sclerosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Surrogate endpoints for EDSS worsening in multiple sclerosis. A meta-analytic approach.

Author: SormaniM P, BonzanoL, RoccatagliataL, MancardiG L, UccelliA, BruzziP

This pooled analysis found a significant correlation between the effect of treatments on relapses and the effect of treatments on EDSS worsening. This supports the use of commonly used surrogate markers of EDSS worsening as endpoints in multiple sclerosis clinical trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

6.

Statins for multiple sclerosis.

Author: WangJin, XiaoYousheng, LuoMan, ZhangXianlong, LuoHongye

This review of 2 trials found insufficient evidence to support statins as an effective treatment for patients with multiple sclerosis (MS). The trials compared atorvastatin plus beta interferon with beta interferon alone for treating MS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Sustained improvement in Expanded Disability Status Scale as a new efficacy measure of neurological change in multiple sclerosis: treatment effects with natalizumab in patients with relapsing multiple sclerosis.

Author: PhillipsJ Theodore, GiovannoniGavin, LublinFred D, O'ConnorPaul W, PolmanChris H, WilloughbyErnie, AschenbachWilliam, PaceAmy, HydeRobert, MunschauerFrederick E

Improved neurological function

Sustained improvement in Expanded Disability Status Scale (EDSS) score is a sensitive measure of treatment effects in multiple sclerosis (MS) and correlates with quality of life. Natalizumab increased the cumulative probability of improvement over 2 years by 69% versus placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

A randomized placebo-controlled cross-over study using a low frequency magnetic field in the treatment of fatigue in multiple sclerosis.

Author: de CarvalhoMaria Laura Lopes, MottaRoberta, KonradGiovanna, BattagliaMario Alberto, BrichettoGiampaolo

Pulsed systemic low-frequency magnetic field therapy did not show any significant advantage over sham therapy in reducing fatigue in patients with multiple sclerosis (MS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

The effects of rivastigmine on processing speed and brain activation in patients with multiple sclerosis and subjective cognitive fatigue.

Author: HuolmanS, HämäläinenP, VorobyevV, RuutiainenJ, ParkkolaR, LaineT, HämäläinenH

Cognitive processing speed improvement

Rivastigmine may improve cognitive processing speed in patients with multiple sclerosis (MS) and subjective cognitive fatigue. A single dose of rivastigmine enhanced compensatory brain activation in patients with MS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Neuropsychological rehabilitation for multiple sclerosis.

Author: Rosti-OtajärviEija M, HämäläinenPäivi I

MS treatment
Reduces cognitive symptoms
None

The review indicates low level evidence for the positive effects of neuropsychological rehabilitation in MS. Well-designed high quality studies are needed to further strengthen the evidence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Statins for multiple sclerosis.

Author: WangJin, XiaoYousheng, LuoMan, LuoHongye

Safe treatment
Ineffective for MS

There is no convincing evidence to support the use of either atorvastatin or simvastatin as an adjunctive therapy in multiple sclerosis (MS). Four trials comparing statins plus interferon beta-1a with interferon beta-1a alone did not show a statistically significant difference in reducing relapses, preventing disease progression, or developing new lesions on MRI.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

MRI lesions as a surrogate for relapses in multiple sclerosis: a meta-analysis of randomised trials.

Author: SormaniMaria Pia, BruzziPaolo

Treatment effects

This study aims to confirm a previous finding that changes in MRI scans and the number of relapses in multiple sclerosis (MS) trials are related to each other. The researchers will use data from a large set of independent MS trials to validate this relationship. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Immunomodulators and immunosuppressants for multiple sclerosis: a network meta-analysis.

Author: FilippiniGraziella, Del GiovaneCinzia, VacchiLaura, D'AmicoRoberto, Di PietrantonjCarlo, BeecherDeirdre, SalantiGeorgia

Improved MS management
MS treatment
Reduced relapse and disability
Needs further research
Unclear optimal therapy

Multiple sclerosis (MS) is treated with various medications, including immunosuppressants, immunomodulators, and monoclonal antibodies. However, it's unclear which treatments are most effective in preventing relapses or disability progression due to a lack of direct comparisons. This study aims to summarize the available evidence, including both direct and indirect comparisons, to provide more clarity on treatment options for MS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Neuropsychological rehabilitation has beneficial effects on perceived cognitive deficits in multiple sclerosis during nine-month follow-up.

Author: Rosti-OtajärviEija, MäntynenAnu, KoivistoKeijo, HuhtalaHeini, HämäläinenPäivi

Improved cognitive deficits

This study evaluated whether short-term neuropsychological rehabilitation has long-term beneficial effects in a nine-month follow-up for patients with multiple sclerosis (MS). The positive effects of neuropsychological rehabilitation on perceived cognitive deficits were maintained for nine months.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Relating relapse and T2 lesion changes to disability progression in multiple sclerosis: a systematic literature review and regression analysis.

Author: FahrbachKyle, HuelinRachel, MartinAmber L, KimEdward, DastaniHoma B, RaoStephen, MalhotraManoj

Reduced relapse rate
Slowed disability progression
Multiple sclerosis

This study examines the link between treatment effects on the frequency of relapses and MRI findings (T2 lesions) in multiple sclerosis (MS) and the overall progression of the disease. The study aims to determine if reducing relapses and specific MRI markers actually translates to slower progression of disability in people with MS, considering different types of MS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Effects of a low-fat diet with antioxidant supplementation on biochemical markers of multiple sclerosis long-term care residents.

Author: MaurizElba, LalienaA, VallejoD, TuñónM J, Rodríguez-LópezJ M, Rodríguez-PérezR, García-FernándezM C

Improved MS symptoms

Currently, treatment options for multiple sclerosis (MS) focus on managing the immune system. However, research on diet suggests that nutrition might play a role in controlling disease progression and improving symptoms in people with MS. This abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Neuropsychological rehabilitation for multiple sclerosis.

Author: Rosti-OtajärviEija M, HämäläinenPäivi I

Cognitive rehabilitation
Neuropsychological rehabilitation
Multiple sclerosis

This review of research on cognitive rehabilitation for multiple sclerosis (MS) highlights the significant impact of cognitive deficits on quality of life for people with MS. The review suggests that addressing these cognitive challenges should be a key focus of MS research and treatment. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Natalizumab in progressive MS: results of an open-label, phase 2A, proof-of-concept trial.

Author: Romme ChristensenJeppe, RatzerRikke, BörnsenLars, LyksborgMark, GardeEllen, DyrbyTim B, SiebnerHartwig R, SorensenPer S, SellebjergFinn

Inflammation reduction
Tissue damage reduction

Natalizumab treatment of progressive MS reduces intrathecal inflammation and tissue damage, supporting a beneficial effect of natalizumab treatment in progressive MS.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Are cognitive interventions for multiple sclerosis effective and feasible?

Author: MagalhãesRosana, AlvesJorge, ThomasRoger E, ChiaravallotiNancy, GonçalvesÓscar F, PetrosyanAgavni, SampaioAdriana

Cognitive intervention
Cognitive impairments
Multiple Sclerosis

This study aimed to assess the effectiveness of cognitive interventions for people with Multiple Sclerosis (MS), a condition that affects the brain and often causes cognitive problems. The study reviewed existing research on this topic to determine if there is clear evidence for the benefits of cognitive interventions. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Predictors of the physical impact of Multiple Sclerosis following community-based, exercise trial.

Author: KehoeM, SaundersJ, JakemanP, CooteS

Minimized physical impact

A randomized controlled trial of 242 people with multiple sclerosis (PwMS) identified fatigue and walking distance at baseline as significant predictors of MSIS-29, v2 (physical component) scores after a 10-week exercise intervention. Exercise was found to be an important contributor to minimizing the physical impact of MS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Subgroups of multiple sclerosis patients with larger treatment benefits: a meta-analysis of randomized trials.

Author: SignoriA, SchiavettiI, GalloF, SormaniM P

Disability progression

Higher treatment effects in relapsing-remitting multiple sclerosis (RRMS) are associated with characteristics of earlier (lower age and Expanded Disability Status Scale) and more active (higher gadolinium activity) disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

22.

Changing EDSS Progression in Placebo Cohorts in Relapsing MS: A Systematic Review and Meta-Regression.

Author: RöverChristian, NicholasRichard, StraubeSebastian, FriedeTim

Regression to the mean

Reviews of research on multiple sclerosis (MS) treatments found that the rate of relapses in placebo groups has decreased over the past 20 years. This may be due to improvements in treatment and the "regression to the mean" effect, where initial measurements are unusually high, and later measurements tend to be closer to the average. The study aims to determine if a similar trend is seen in the progression of disability, measured using the EDSS scale.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Patient education for people with multiple sclerosis-associated fatigue: A systematic review.

Author: WendebourgMaria Janina, HeesenChristoph, FinlaysonMarcia, MeyerBjörn, PöttgenJana, KöpkeSascha

Improved MS quality of life
MS treatment
Potential for non-pharmacological interventions
Limited pharmacological effectiveness
Needs further research

Multiple sclerosis (MS) is a debilitating disease that can impact quality of life, social interaction, and employment. While medications have had limited success, non-pharmacological interventions, such as education programs for patients, show promising results.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Indirect comparisons of treatment effects: Network meta-analyses.

Author: SormaniMaria Pia

There are many different medications available for multiple sclerosis (MS), but they haven't been directly compared to each other in clinical trials. This article describes a method called "network meta-analysis" that can be used to indirectly compare the effectiveness of different treatments for MS. The abstract does not provide specific results, only a discussion of the method. Therefore, we cannot provide a summary of the study's findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

25.

Sex differences in outcomes of disease-modifying treatments for multiple sclerosis: A systematic review.

Author: LiRui, SunXiaobo, ShuYaqing, MaoZhifeng, XiaoLi, QiuWei, LuZhengqi, HuXueqiang

This study aims to examine whether men and women with multiple sclerosis (MS) respond differently to medications that modify the immune system (DMTs). The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

The Use of Noncontrast Quantitative MRI to Detect Gadolinium-Enhancing Multiple Sclerosis Brain Lesions: A Systematic Review and Meta-Analysis.

Author: GuptaA, Al-DasuqiK, XiaF, AskinG, ZhaoY, DelgadoD, WangY

Assessment of MS lesion acuity

Noncontrast MR imaging techniques, such as DTI-based FA, can assess MS lesion acuity without gadolinium.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Computer-assisted cognitive rehabilitation in persons with multiple sclerosis: Results of a multi-site randomized controlled trial with six month follow-up.

Author: StuifbergenAlexa K, BeckerHeather, PerezFrancisco, MorrisonJanet, BrownAdama, KullbergVicki, ZhangWenhui

Cognitive management
Improved MS management
MS treatment
Limited treatment options
Needs further research

Cognitive problems are a significant aspect of multiple sclerosis (MS) that can severely affect quality of life. Despite their prevalence, few strategies exist to manage these cognitive changes in people with MS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

29.

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension.

Author: KapoorRaju, HoPei-Ran, CampbellNolan, ChangIh, DeykinAaron, ForrestalFiona, LucasNisha, YuBei, ArnoldDouglas L, FreedmanMark S, GoldmanMyla D, HartungHans-Peter, HavrdováEva Kubala, JefferyDouglas, MillerAaron, SellebjergFinn, CadavidDiego, MikolDan, SteinerDeborah,

Slowed MS progression

While treatments exist for multiple sclerosis (MS) that involves relapses, they have had less success for those with progressive MS. This study aims to determine whether a specific medication, natalizumab, can slow the progression of secondary progressive MS, even in patients who are not having relapses.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Adverse psychiatric effects of disease-modifying therapies in multiple Sclerosis: A systematic review.

Author: GasimMajid, BernsteinCharles N, GraffLesley A, PattenScott B, El-GabalawyRenee, SareenJitender, BoltonJames M, MarriottJames J, FiskJohn D, MarrieR A,

Reduced depression
Adverse psychiatric effects

Second-generation disease-modifying therapies (DMTs) for multiple sclerosis (MS) were not associated with an increased risk of adverse psychiatric effects. Some DMTs, like fingolimod, may even reduce the incidence of depressive symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Assessment of Efficacy and Tolerability of Medicinal Cannabinoids in Patients With Multiple Sclerosis: A Systematic Review and Meta-analysis.

Author: Torres-MorenoMari Carmen, PapaseitEsther, TorrensMarta, FarréMagí

bladder dysfunction reduction
pain reduction
spasticity reduction
adverse effects

Cannabinoids showed limited efficacy in the treatment of spasticity, pain, and bladder dysfunction in patients with multiple sclerosis (MS). However, cannabinoid therapy was considered safe.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis.

Author: HooijmansCarlijn R, HlavicaMartin, SchulerFlorian A F, GoodNicolas, GoodAndrin, BaumgartnerLisa, GalenoGianluca, SchneiderMarc P, JungTarzis, de VriesRob, IneichenBenjamin V

MS remyelination
MS treatment

This study reviewed 88 different potential treatments for repairing the myelin sheath, which is damaged in multiple sclerosis (MS). 25 of these treatments have progressed to human clinical trials. The review identified 16 promising treatments that haven't yet been tested in humans, including Pigment epithelium-derived factor, Platelet-derived growth factor, and Tocopherol derivative TFA-12. The study also found that the quality of research in animal models can impact the translation of treatments into human trials, suggesting that improvements in research methods could lead to more successful treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Comparative efficacy and acceptability of disease-modifying therapies in patients with relapsing-remitting multiple sclerosis: a systematic review and network meta-analysis.

Author: LiHuihui, HuFengli, ZhangYanli, LiKai

DMTs
Improved MS management
MS treatment
Needs further research
Unclear optimal therapy

This study reviewed research on the effects of different disease-modifying therapies (DMTs) for multiple sclerosis (MS). The goal is to understand how these medications, which are designed to slow the progression of MS, impact the overall course of the disease and patient outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Effects of Nonpharmaceutical Treatments on Symptom Management in Adults With Mild or Moderate Multiple Sclerosis: A Meta-analysis.

Author: ByrnesKeira Leigh, WhillierStephney

Balance
Fatigue
Functionality
Quality of life

Nonpharmaceutical treatments, such as physical activity, rehabilitation, resistance training, and alternative approaches, can improve fatigue, functionality, balance, and quality of life in patients with multiple sclerosis (MS). Psychological approaches had a small effect on improving quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

36.

Is diet associated with physical capacity and fatigue in persons with multiple sclerosis? -Results from a pilot study.

Author: AlbrechtsenM T, Langeskov-ChristensenM, JørgensenM L K, DalgasU, HansenM

Diet

While diet may have the potential to help manage multiple sclerosis (MS), research on the role of nutrition in MS is inconclusive. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

Disease-modifying treatments and cognition in relapsing-remitting multiple sclerosis: A meta-analysis.

Author: LandmeyerNils C, BürknerPaul-Christian, WiendlHeinz, RuckTobias, HartungHans-Peter, HollingHeinz, MeuthSven G, JohnenAndreas

Improved MS treatment

This study reviewed research on the effects of various medications (DMTs) for multiple sclerosis (MS) on cognitive function in people with relapsing-remitting MS (RRMS). The study aimed to compare how these medications affect cognitive performance. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Effects of Ibudilast on MRI Measures in the Phase 2 SPRINT-MS Study.

Author: NaismithRobert T, BermelRobert A, CoffeyChristopher S, GoodmanAndrew D, FedlerJanel, KearneyMarianne, KlawiterEric C, NakamuraKunio, NarayananSridar, GoebelChristopher, YankeyJon, KlingnerElizabeth, FoxRobert J,

Gray matter atrophy
New lesions

Ibudilast, a drug commonly used for asthma, was found to be ineffective at reducing new or enlarging T2 lesions or new T1 lesions in patients with progressive forms of multiple sclerosis (MS). However, ibudilast was associated with a reduction in gray matter atrophy. This suggests that ibudilast may affect markers associated with neurodegenerative processes, but not inflammatory processes, in patients with MS.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

A randomized controlled trial of a web-based mindfulness programme for people with MS with and without a history of recurrent depression.

Author: SeselAmy-Lee, SharpeLouise, BeadnallHeidi N, BarnettMichael H, SzaboMarianna, NaismithSharon L

Depressive symptom improvement
HRQoL improvement

An Internet-delivered mindfulness-based intervention (MBI) significantly improved depressive symptoms and health-related quality of life (HRQoL) in people with multiple sclerosis (PwMS). The benefits were greater for those with a history of recurrent depression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

41.

Post marketing new adverse effects of oral therapies in multiple sclerosis: A systematic review.

Author: SahraianMohammad Ali, SalehiAmir Mohammad, JenabiEnsiyeh, EsfahaniMaryam Etminani, AtaeiSara

Post-marketing side effects of DMDs for MS

While medications called disease-modifying drugs (DMDs) are used to manage multiple sclerosis (MS), there isn't enough information about the side effects that may occur after they are released to the market. This review aimed to identify the DMDs used for MS and to highlight the need for more research on their safety profile.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

42.

A systematic review and meta-analysis of the effects of non-pharmacological interventions on quality of life in adults with multiple sclerosis.

Author: GitmanVictor, MossKasey, HodgsonDavid

Increased QoL
Non-pharmacological interventions
MS

This review aims to comprehensively examine research on non-medication approaches (non-pharmacological interventions) to improve quality of life for people with multiple sclerosis (MS). The review notes that while there is no cure for MS, finding ways to improve quality of life is a critical area of research. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

43.

Adverse effects of immunotherapies for multiple sclerosis: a network meta-analysis.

Author: TramacereIrene, VirgiliGianni, PerducaVittorio, LucenteforteErsilia, BenedettiMaria Donata, CapobussiMatteo, CastelliniGreta, FrauSerena, Gonzalez-LorenzoMarien, FeatherstoneRobin, FilippiniGraziella

Decreased disease activity
MS treatment
Safety uncertainty
Significant disability

Multiple sclerosis (MS) is a disease affecting the brain and spinal cord, primarily affecting young adults, with women being affected more often than men. While treatments for MS can slow the disease's progression, there's still uncertainty about their safety.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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