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Pharmacokinetic and pharmacodynamic evaluations of the zwitterionic metabolite of a new series of N-substituted soft anticholinergics.

Author: BodorNicholas, BuchwaldPeter, JiFubao, MoriNobuhiro, WuJiaXiang, WuWhei-Mei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

N-substituted zwitterionic metabolites retain some, but only considerably reduced activity of their parent quaternary ammonium ester soft anticholinergic drugs. They are very rapidly eliminated from the systemic circulation and are suitable for use in inactive metabolite-based soft anticholinergic design.
Paper Details　
Original Abstract of the Article :
PURPOSE: This study was conducted to evaluate the zwitterionic common metabolite of a novel series of N-substituted soft analogs of glycopyrrolate both as racemates and as 2R isomers. METHODS: Activities were assessed using both in vitro (receptor binding assay, guinea pig ileum pA2 assay) and in v...See full text at original site
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引用元：
https://doi.org/10.1007/s11095-005-8174-z

データ提供：米国国立医学図書館（NLM）

Zwitterionic Metabolite of Soft Anticholinergics: A New Oasis in the Desert of Drug Development

Developing effective drugs involves a complex interplay of factors, including the drug's chemical properties and its breakdown products. This research delves into the pharmacokinetic and pharmacodynamic properties of a zwitterionic metabolite of a new series of soft anticholinergics. It's like studying the evolution of a desert plant, observing how it adapts to harsh conditions and produces unique metabolites.

A Novel Metabolite: A Unique Oasis in the Desert of Drug Design

The study explores the properties of a zwitterionic metabolite, a breakdown product of a new series of soft anticholinergics. It's like discovering a hidden oasis in the desert, revealing a unique and potentially beneficial component. The study found that the metabolite is rapidly eliminated from the body and has significantly reduced activity compared to its parent drug, suggesting a potential advantage in terms of safety and side effects.

Implications for Drug Development

This research highlights the importance of considering the properties of drug metabolites in drug development. It's like navigating a desert landscape, understanding the impact of each element on the overall journey. The study's findings suggest that the zwitterionic metabolite may contribute to the safety profile of the parent drug, offering a promising avenue for developing more effective and well-tolerated medications.

Dr.Camel's Conclusion

This research delves into the intricate world of drug metabolites, exploring the properties of a zwitterionic metabolite of a new series of soft anticholinergics. The study's findings, like finding a rare desert flower, reveal the potential for developing safer and more effective medications. This research is a reminder of the vast and often hidden complexities in the desert of drug development.
Date :
  1. Date Completed 2006-03-09
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

16170596

DOI: Digital Object Identifier

10.1007/s11095-005-8174-z

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Languages

English

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