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Methadone doses of 100 mg or greater are more effective than lower doses at suppressing heroin self-administration in opioid-dependent volunteers.

Author: BigelowGeorge E, BrasserSusan M, DonnyEric C, StitzerMaxine L, WalshSharon L

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Methadone maintenance has been a successful treatment for heroin addiction for many years. Recent studies suggest that higher doses of methadone than typically used may be even more effective in reducing heroin use. This could be because higher doses create greater resistance to the pleasurable effects of heroin.
Paper Details　
Original Abstract of the Article :
Methadone maintenance has been an effective pharmacotherapy for the treatment of heroin dependence for nearly four decades. Recent clinical research suggests that methadone doses larger than those used in most clinics are more effective at suppressing illicit heroin use. This greater efficacy may re...See full text at original site
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引用元：
https://doi.org/10.1111/j.1360-0443.2005.01232.x

データ提供：米国国立医学図書館（NLM）

Methadone Dosing: Higher Doses Show Promise for Heroin Dependence Treatment

The [treatment of heroin dependence] is a complex and challenging endeavor. This research investigates the [effectiveness of different methadone doses] in [suppressing heroin self-administration] in [opioid-dependent volunteers]. The researchers used a [controlled study] to compare the effects of [methadone doses of 100 mg or greater] to [lower doses]. Their findings suggest that [higher methadone doses are more effective at reducing heroin use].

Higher Methadone Doses: A More Effective Approach

This study demonstrates that [higher methadone doses can significantly reduce heroin use]. The findings support the idea that [higher doses may lead to greater cross-tolerance to heroin's reinforcing effects].

Tailoring Treatment for Optimal Outcomes

This research underscores the importance of [individualizing treatment plans] for [opioid dependence]. It's like navigating a desert with different paths leading to the same destination. The right approach for one individual may not be the right approach for another.

Dr. Camel's Conclusion

This study adds another layer to the complex landscape of opioid dependence treatment. It's like discovering a new oasis in the desert, offering potential relief for those struggling with heroin addiction. However, it's important to recognize that higher methadone doses may also increase the risk of side effects. Therefore, careful monitoring and individualized treatment plans are crucial for ensuring optimal outcomes for patients.

Date :
  1. Date Completed 2006-01-25
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16185211

DOI: Digital Object Identifier

10.1111/j.1360-0443.2005.01232.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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