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Effects of ATRA, acitretin and tazarotene on growth and apoptosis of Tca8113 cells.
Author: RanLiwei, TanShengshun, TanWeiming, WangWanjuan, ZengWeihui, ZhangRu
Original Abstract of the Article :
To investigate the effects of ATRA, acitretin and tazarotene on the growth and apoptosis of human tongue squamous cell carcinoma cell line Tca8113. The effect of retinoids on growth of Tca8113 cells in vitro was examined by MTT assay and Trypan blue exclusion assay. Cell cycle analysis, early apopto...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/BF02828205
データ提供:米国国立医学図書館(NLM)
Retinoids' Effects on Human Tongue Squamous Cell Carcinoma Cells
This study explores the potential therapeutic effects of retinoids, a class of vitamin A derivatives, on human tongue squamous cell carcinoma cells (Tca8113). The authors investigated the effects of all-trans retinoic acid (ATRA), acitretin, and tazarotene on the growth and apoptosis of these cancer cells. Their findings demonstrate that all three retinoids inhibited the growth of Tca8113 cells in a dose- and time-dependent manner. They also found that retinoids induced apoptosis in these cells, potentially through a caspase-dependent mechanism. The study highlights the promising anticancer potential of retinoids for the treatment of tongue squamous cell carcinoma.
Retinoids as Potential Anticancer Agents for Tongue Squamous Cell Carcinoma
This study provides evidence for the anticancer effects of retinoids on tongue squamous cell carcinoma cells. The study's findings suggest that retinoids, particularly acitretin, may have therapeutic potential for the treatment and prevention of this type of cancer.
Health Implications and Life Applications
Tongue squamous cell carcinoma is a serious condition, but this study offers hope for new treatment options. The study's findings highlight the potential benefits of retinoids in treating this type of cancer, potentially leading to improved patient outcomes.
Dr. Camel's Conclusion
This research is like finding a hidden spring of hope in the vast desert of cancer treatment. Retinoids, like a refreshing oasis, offer potential new avenues for combating tongue squamous cell carcinoma. This study encourages continued research into the therapeutic potential of retinoids for the treatment of various types of cancer.
Date :
- Date Completed 2007-10-09
- Date Revised 2019-11-09
Further Info :
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