Paper Details

  1. Home
  2. Paper Details

Prophylactic intravenous ondansetron and dolasetron in intrathecal morphine-induced pruritus: a randomized, double-blinded, placebo-controlled study.

Author: DimitriouVasilios K, DragoumanisChristos K, IatrouChristos A, SimopoulosConstantinos E, VogiatzakiTheodosia D, VretzakisGeorge I

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Ondansetron and dolasetron were evaluated for the prevention of intrathecal morphine-induced pruritus in a prospective, randomized, double-blind, placebo-controlled study. The incidence and severity of pruritus was significantly less frequent in the ondansetron and dolasetron groups compared with placebo.
Paper Details　
Original Abstract of the Article :
Pruritus is the most common side effect of intrathecal morphine for postoperative pain relief. Activation of central 5-hydroxytryptamine subtype 3 (5-HT3) receptors is one of its possible mechanisms. The role of 5-HT3 antagonists in the prevention of pruritus has not been clearly established. In a p...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1213/01.ANE.0000181338.35454.6A

データ提供：米国国立医学図書館（NLM）

Preventing Itch: Ondansetron and Dolasetron for Intrathecal Morphine-Induced Pruritus

The study investigates the unwelcome side effect of intrathecal morphine - pruritus, or itch. It's like a pesky camel fly, buzzing around, making you want to scratch. The authors examined the effectiveness of two 5-HT3 antagonists, ondansetron and dolasetron, in preventing this itch. They found that both medications were significantly more effective than a placebo in reducing the incidence and severity of pruritus.

Ondansetron and Dolasetron: A Double-Whammy Against Itch

This study provides compelling evidence that ondansetron and dolasetron can be valuable tools in managing post-operative itch associated with intrathecal morphine. It's like a double-pronged attack against the pesky camel fly, leaving you feeling much more comfortable after surgery.

Relief from the Itch: Improved Quality of Life

By effectively preventing or reducing pruritus, these medications can significantly improve the quality of life for patients recovering from surgery. Imagine a post-surgery recovery without the constant irritation of itch - it's like a cool oasis in the heat of recovery!

Dr.Camel's Conclusion

This study offers a glimmer of hope for patients who experience post-operative itch. By using ondansetron or dolasetron, they can avoid the annoying and sometimes debilitating itch, which can help them focus on their recovery. It's a great example of how research can provide practical solutions for common problems.
Date :
  1. Date Completed 2005-11-22
  2. Date Revised 2021-09-02
Further Info :

Pubmed ID

16244023

DOI: Digital Object Identifier

10.1213/01.ANE.0000181338.35454.6A

Related Literature

Article Analysis
・Effects of dolasetron injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.