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Successive clinical trials for childhood acute myeloid leukemia at St Jude Children's Research Hospital, from 1980 to 2000.

Author: HijiyaN, PoundsS, PuiC-H, RazzoukB I, RibeiroR C, RubnitzJ E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study analyzed the results of five leukemia treatment studies in children with newly diagnosed acute myeloid leukemia (AML) over 20 years. While overall survival improved over time, only about 50% of patients were cured, with most treatment failures due to resistant or relapsed leukemia. Increasing chemotherapy intensity or prolonging post-remission therapy did not improve outcomes. The study suggests that more targeted treatments are needed for different types of AML, rather than using the same approach for everyone.
Paper Details　
Original Abstract of the Article :
Despite substantial progress in the management of childhood acute myeloid leukemia (AML), only about 50% of patients are cured by intensive chemotherapy. The long-term results of clinical trials may reveal principles that can guide the development of future therapy. From 1980 to 2000, 251 patients <...See full text at original site
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引用元：
https://doi.org/10.1038/sj.leu.2403872

データ提供：米国国立医学図書館（NLM）

A Journey Through Time: Evolving Treatments for Childhood Acute Myeloid Leukemia

This study takes us on a fascinating journey through time, examining the evolution of treatment strategies for childhood acute myeloid leukemia (AML) at St. Jude Children's Research Hospital from 1980 to 2000. This research is a testament to the relentless pursuit of effective therapies for a devastating disease. The authors analyze the outcomes of five consecutive clinical trials, highlighting the progress made and the challenges that remain.

The Quest for Cures: Progress and Challenges in AML Treatment

Despite significant advancements, the treatment of childhood AML remains a complex endeavor. This study reveals that while survival rates have improved over the decades, a significant proportion of patients still experience treatment failures. The authors underscore the need for subtype-specific therapies to address the heterogeneity of AML, a critical step towards achieving better outcomes. It's like navigating a vast desert, seeking out the best pathways to conquer the disease.

AML Treatment: A Multifaceted Approach

This research emphasizes the importance of a multidisciplinary approach to treating childhood AML. It highlights the need for careful consideration of various treatment options, including chemotherapy regimens and potential future therapies. This approach is like finding a hidden oasis in the desert, relying on a combination of resources to ensure survival.

Dr.Camel's Conclusion

This research paints a vivid picture of the ongoing struggle against childhood acute myeloid leukemia. While progress has been made, the journey towards effective cures continues. The authors have meticulously documented the evolution of treatment strategies, highlighting the need for individualized approaches and the promise of subtype-specific therapies. This research is a beacon of hope in the desert of pediatric cancer, reminding us that the search for cures is a constant and vital endeavor.

Date :
  1. Date Completed 2006-01-19
  2. Date Revised 2013-03-04
Further Info :

Pubmed ID

16281077

DOI: Digital Object Identifier

10.1038/sj.leu.2403872

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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