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Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.

Author: ClyneColin D, GaillardStéphanie, KovacicAgnes, McDonnellDonald P, MurataYoko, SafiRachid, SimpsonEvan R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

This study investigates the role of liver receptor homologue-1 (LRH-1) in the regulation of aromatase gene expression in human breast preadipocytes. The findings suggest that LRH-1 is a specific transcriptional activator of aromatase in breast tissue and may be a potential target for selective inhibition of aromatase production in breast cancer.
Paper Details　
Original Abstract of the Article :
Aromatase inhibitors target the production of estrogen in breast adipose tissue, but in doing so, also decrease estrogen formation in bone and other sites, giving rise to deleterious side effects, such as bone loss and arthralgia. Thus, it would be clinically useful to selectively inhibit aromatase ...See full text at original site
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引用元：
https://doi.org/10.1158/0008-5472.CAN-05-2792

データ提供：米国国立医学図書館（NLM）

Aromatase Inhibition: A Quest for Breast Cancer Specificity

This study, published in [Journal Name], explores the intricacies of aromatase inhibition, a key strategy in breast cancer therapy. The researchers meticulously investigate the role of the orphan nuclear receptor liver receptor homologue-1 (LRH-1) and its coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) in regulating aromatase gene expression.

The Intricate Regulation of Aromatase

The study unveils the complex regulation of aromatase gene expression, highlighting the crucial roles of LRH-1 and PGC-1alpha in this process. The research team identifies a potential pathway for selectively inhibiting aromatase production in breast tissue while sparing other sites of expression, paving the way for more targeted and less-invasive therapies.

A New Frontier in Breast Cancer Treatment

This research opens up exciting new avenues for breast cancer treatment. By understanding the molecular mechanisms underlying aromatase regulation, we can develop more specific and effective therapies, minimizing side effects and improving patient outcomes.

Dr. Camel's Conclusion

This study underscores the remarkable power of molecular research in developing precise and personalized therapies. By carefully navigating the intricate network of cellular pathways, we can gain valuable insights into disease mechanisms and design targeted treatments that minimize collateral damage.

Date :
  1. Date Completed 2006-02-23
  2. Date Revised 2018-12-03
Further Info :

Pubmed ID

16357189

DOI: Digital Object Identifier

10.1158/0008-5472.CAN-05-2792

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Languages

English

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