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Antitumor effects of etodolac, a selective cyclooxygenase-II inhibitor, against human prostate cancer cell lines in vitro and in vivo.

Author: FujisawaMasato, GotohAkinobu, KamidonoSadao, ShigemuraKatsumi, ShirakawaToshiro, WadaYoshitaka

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Etodolac, a cyclooxygenase-2 (COX-2) inhibitor, exhibited an antitumor effect on prostate cancer cell lines in vitro and in vivo. It may be useful for the treatment of hormone-resistant prostate cancer.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To investigate the effects of the selective cyclooxygenase-2 (COX-2) inhibitor etodolac on prostate cancer cell lines in vitro and in vivo and on E-cadherin expression in prostate cancer cells. METHODS: We evaluated the cytotoxicity of etodolac on the three prostate cancer cell lines LN...See full text at original site
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引用元：
https://doi.org/10.1016/j.urology.2005.06.076

データ提供：米国国立医学図書館（NLM）

Etodolac: A Potential Weapon Against Prostate Cancer?

Prostate cancer is a significant health concern for men worldwide. This study investigates the potential antitumor effects of etodolac, a selective cyclooxygenase-2 (COX-2) inhibitor commonly used to treat pain and inflammation, against human prostate cancer cell lines.

The study evaluated the effects of etodolac on prostate cancer cells both in vitro (using laboratory cultures) and in vivo (using animal models). It's like testing a new weapon in a controlled environment, carefully observing its effects on both a target practice range and a simulated battlefield.

Etodolac Shows Anti-tumor Potential

The study found that etodolac exhibited significant antitumor effects both in vitro and in vivo. It's like discovering a potent antidote to a desert plague, offering a promising solution to a serious health threat. The drug appeared to inhibit tumor growth and potentially alter the expression of key proteins involved in cancer development.

A New Avenue for Prostate Cancer Treatment?

This research provides encouraging evidence for the potential of etodolac as a treatment option for prostate cancer. It's like finding a hidden oasis in the vast desert of cancer research, offering a potential new path to combat this devastating disease. Further research is needed to confirm these findings and explore the optimal use of etodolac in clinical settings.

Dr.Camel's Conclusion

This research offers a hopeful perspective on the potential of etodolac as a treatment option for prostate cancer. It's like finding a hidden oasis in the vast desert of cancer research, offering a potential new path to combat this devastating disease. While further research is needed to confirm these findings and explore the optimal use of etodolac in clinical settings, this study provides encouraging evidence for the potential of this drug in fighting prostate cancer.

Date :
  1. Date Completed 2006-01-26
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16360450

DOI: Digital Object Identifier

10.1016/j.urology.2005.06.076

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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