Cyclosporine in the treatment of severe attack of ulcerative colitis: a systematic review.

Author: García-LópezS, Gomollón-GarcíaF, Pérez-GisbertJ

Paper Details 
Original Abstract of the Article :
INTRODUCTION: Intravenous steroid therapy is the standard treatment in severe attacks of ulcerative colitis (UC), but 20% to 60% of patients fail to respond and require colectomy. Cyclosporine (CyA) has shown efficacy in steroid failures and could avoid surgery, but controversy remains. AIM: The ob...See full text at original site
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引用元:
https://doi.org/10.1016/s0210-5705(05)71523-5

データ提供:米国国立医学図書館(NLM)

Cyclosporine: A Potential Oasis in the Storm of Ulcerative Colitis

Ulcerative colitis (UC), a chronic inflammatory bowel disease, can be a debilitating condition that can significantly impact an individual's quality of life. This study examines the use of cyclosporine (CyA), an immunosuppressant medication, in treating severe attacks of UC, particularly in patients who have not responded to traditional steroid therapies. The researchers conduct a systematic review of existing literature, analyzing the efficacy and safety of CyA in inducing remission in patients with severe UC. Their findings suggest that CyA, particularly when administered intravenously at lower doses, can be an effective and relatively safe treatment option for patients with severe, steroid-refractory UC.

Finding a Path Through the Storm: CyA's Impact on UC

This study offers a beacon of hope for individuals suffering from severe UC, demonstrating the effectiveness of CyA in inducing remission in patients who have not responded to traditional therapies. This finding provides a potential treatment option for individuals struggling with this condition, a condition that can severely disrupt their daily lives. It's like finding a safe haven in the midst of a raging storm, offering a sense of relief and a chance for healing.

Navigating the Storm: Understanding the Potential of CyA

While the study highlights the potential of CyA, it also emphasizes the importance of carefully selecting patients and monitoring their responses to medication. The researchers underscore the need for individualized treatment plans, taking into account potential side effects and carefully managing the administration of CyA. It's a reminder that navigating the storm of UC requires a cautious and personalized approach, ensuring that patients receive the most effective and safe treatment possible.

Dr. Camel's Conclusion

This study provides valuable insights into the potential of CyA as a treatment for severe UC, particularly in patients who have not responded to traditional therapies. It encourages further research to refine the optimal dosage and administration of CyA, ensuring that this medication is used safely and effectively. It's a reminder that navigating the storm of UC requires a multifaceted approach, embracing every tool and strategy available to improve patient outcomes and reduce the burden of this debilitating disease.

Date :
  1. Date Completed 2006-05-03
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

16373009

DOI: Digital Object Identifier

10.1016/s0210-5705(05)71523-5

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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