Increase in tumor oxygenation and potentiation of radiation effects using pentoxifylline, vinpocetine and ticlopidine hydrochloride.

Author: AmanoMorikazu, AndohSatoshi, HasegawaTakeo, MonzenHajime, SuzukiMinoru, TeraiKaoru, TsumurayaAkio

Paper Details 
Original Abstract of the Article :
The purpose of the present study was to investigate the effects of Pentoxifylline (PTX), Vinpocetine (VPT) and Ticlopidine Hydrochloride (TCD), used commonly for vascular disorders in humans, on the pO2 in SCCVII tumors of C3H/HeJ mice and on the radioresponse of SCCVII tumors. The pO2 in the SCCVII...See full text at original site
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引用元:
https://doi.org/10.1269/jrr.46.373

データ提供:米国国立医学図書館(NLM)

Boosting Radiation Therapy with Pentoxifylline, Vinpocetine, and Ticlopidine

Cancer treatment is often a battle fought on multiple fronts, requiring a combination of strategies to combat this challenging disease. This study investigates the potential for enhancing radiation therapy with the drugs pentoxifylline, vinpocetine, and ticlopidine, commonly used for vascular disorders. It's like adding a new weapon to an arsenal, seeking to improve the effectiveness of a tried-and-true method. The researchers found that these drugs increased oxygen levels in tumor cells, which could potentially enhance the effectiveness of radiation therapy. They observed significant tumor growth delays in groups treated with a combination of drugs and radiation.

Improving Radiation Therapy Outcomes

This research explores the potential for enhancing radiation therapy with drugs that improve blood flow and oxygenation. It's like finding a new source of energy for a desert expedition, providing a boost to the existing resources. The researchers' findings highlight the potential to improve the efficacy of radiation therapy by addressing the limitations of oxygen availability in tumor cells.

A More Effective Weapon Against Cancer

This study suggests that the combination of radiation therapy and drugs that improve oxygen levels in tumor cells could be a powerful strategy for combating cancer. It's like combining the strength of a caravan with the agility of a camel, creating a formidable force against a challenging adversary. The researchers' findings offer a promising avenue for enhancing cancer treatment, providing a more effective and targeted approach to combat this disease.

Dr.Camel's Conclusion

This study explores the potential for improving radiation therapy outcomes by enhancing oxygen levels in tumor cells. The researchers' findings offer a promising avenue for enhancing the effectiveness of this vital cancer treatment modality, providing a more potent weapon in the fight against this formidable foe.
Date :
  1. Date Completed 2006-02-28
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

16394626

DOI: Digital Object Identifier

10.1269/jrr.46.373

Related Literature

SNS
PICO Info
in preparation
Languages

English

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