Effects of oxymorphone and hydromorphone on the minimum alveolar concentration of isoflurane in dogs.

Author: DysonDoris H, Grant MaxieM, MachadoCarmen E G

Paper Details 
Original Abstract of the Article :
OBJECTIVES: To quantify the change in the minimum alveolar concentration (MAC) of isoflurane (ISO) associated with oxymorphone (OXY) or hydromorphone (HYDRO) in dogs. DESIGN: Randomized crossover study with at least 1 week between assessments. ANIMALS: Six young, healthy, mixed-breed dogs (1-3 yea...See full text at original site
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引用元:
https://doi.org/10.1111/j.1467-2995.2005.00215.x

データ提供:米国国立医学図書館(NLM)

Oxymorphone and Hydromorphone: Reducing Isoflurane Requirements in Dogs

This study ventures into the world of [veterinary anesthesia] and investigates the effects of oxymorphone and hydromorphone on the minimum alveolar concentration (MAC) of isoflurane in dogs. The authors conducted a randomized crossover study to quantify the MAC-sparing effects of these two opioids. They found that both oxymorphone and hydromorphone significantly reduced the MAC of isoflurane, suggesting a potential for reduced anesthetic requirements and improved patient safety. However, the duration of these effects differed, with hydromorphone providing a longer-lasting MAC-sparing effect. This study offers valuable insights into the potential of these opioids for improving anesthetic management in dogs.

Opioids Show Promise for Reducing Anesthetic Requirements in Dogs

The study's findings demonstrate the potential of oxymorphone and hydromorphone to reduce the MAC of isoflurane in dogs, suggesting that lower doses of isoflurane could be used while achieving adequate anesthetic depth. This could lead to improved patient safety and reduced side effects. The study also highlights the longer-lasting effects of hydromorphone, making it a potentially better choice for longer procedures.

Optimizing Anesthesia in Dogs: Exploring the Potential of Opioids

The findings of this study offer valuable insights for veterinarians seeking to optimize anesthetic management in dogs. Opioids like oxymorphone and hydromorphone may play a significant role in reducing anesthetic requirements and improving patient safety. However, it's crucial for veterinarians to carefully consider the individual needs of each patient and the potential for side effects associated with opioids.

Dr.Camel's Conclusion

This study, like a caravan traversing a desert, sheds light on the potential of opioids to improve anesthetic management in dogs. The findings suggest that these medications can effectively reduce isoflurane requirements, offering a safer and more efficient approach to anesthesia. This research is a testament to the ongoing efforts to improve animal health and well-being.

Date :
  1. Date Completed 2007-04-03
  2. Date Revised 2017-04-08
Further Info :

Pubmed ID

16412134

DOI: Digital Object Identifier

10.1111/j.1467-2995.2005.00215.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

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