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The use of metformin for women with PCOS undergoing IVF treatment.

Author: BalenAdam H, BarthJulian H, GlanvilleJulie, OrsiNic, TangThomas

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Metformin does not improve the response to stimulation in women with PCOS undergoing IVF/ICSI cycles, but it does significantly improve the pregnancy outcome and reduces the risk of OHSS.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Metformin appears to improve reproductive function in some women with polycystic ovary syndrome (PCOS). We wished to explore the effect of metformin in women with PCOS undergoing IVF. METHODS: A randomized, placebo-controlled, double-blind study was carried out between 2001 and 2004. Pa...See full text at original site
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引用元：
https://doi.org/10.1093/humrep/del025

データ提供：米国国立医学図書館（NLM）

Metformin: A Potential Ally in IVF Treatment for PCOS

In the field of [reproductive medicine], [polycystic ovary syndrome] (PCOS) presents a significant challenge, affecting fertility and posing challenges for women seeking to conceive. This research investigates the potential benefits of [metformin] in women with PCOS undergoing [in vitro fertilization] (IVF) treatment. The study employs a [randomized, placebo-controlled, double-blind design] to evaluate the impact of metformin on IVF outcomes, providing valuable insights into its potential role in improving pregnancy rates.

Metformin's Positive Impact on IVF Outcomes

The study reveals that [short-term metformin co-treatment] may significantly improve [clinical pregnancy rates] in women with PCOS undergoing IVF. While metformin did not affect [ovulation induction] or [fertilization rates], it significantly enhanced [pregnancy rates] and reduced the incidence of [severe ovarian hyperstimulation syndrome] (OHSS). These findings suggest a potential benefit of metformin in optimizing IVF outcomes for women with PCOS.

Improving IVF Success for Women with PCOS

This research underscores the potential for [metformin] to enhance IVF success for women with PCOS. The study's findings suggest that metformin may play a role in [improving endometrial receptivity] or [modulating hormonal imbalances] associated with PCOS, ultimately contributing to higher pregnancy rates. Further research is needed to fully elucidate the mechanisms underlying metformin's beneficial effects in this context, but this study provides encouraging evidence for its potential use in IVF treatment for PCOS.

Dr.Camel's Conclusion

Just as a camel adapts to the arid desert, women with PCOS navigate the challenges of infertility. This research suggests that metformin, like a cool oasis, can provide a supportive environment for IVF success. By understanding the potential benefits of metformin, we can empower women with PCOS to pursue their dreams of parenthood.

Date :
  1. Date Completed 2006-11-09
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

16501038

DOI: Digital Object Identifier

10.1093/humrep/del025

Related Literature

Article Analysis
・Effective treatment of polycystic ovary syndrome
SNS
PICO Info
in preparation
Languages

English

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