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Remission induction chemotherapy induces in vivo caspase-dependent apoptosis in bone marrow acute myeloid leukemia blast cells and spares lymphocytes.

Author: BellocF, LacombeF, PigneuxA, PraloranV, TabriziR, VialJ-P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The increase of peripheral apoptotic blast cells cannot be considered as the earliest marker of the treatment efficiency in AML patients receiving remission induction treatment. Less than 50% of apoptosis, measured with the fmk-VAD-FITC, in the d15 residual bone marrow blast cells, correlated with lower disease-free survival probability.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The goal of new therapeutic strategies is to adapt the treatment of acute myeloid leukemia (AML) patients to the prognostic and/or to the hematological response. METHODS: We analyzed in vivo apoptosis induction in blast cells and in lymphocytes of AML patients receiving remission induct...See full text at original site
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引用元：
https://doi.org/10.1002/cyto.b.20105

データ提供：米国国立医学図書館（NLM）

Targeting Leukemia Cells with Chemotherapy

Acute myeloid leukemia (AML) is a type of cancer that affects the bone marrow. Remission induction chemotherapy is a standard treatment for AML, aiming to eliminate leukemia cells and achieve remission. This study investigates the effects of remission induction chemotherapy on apoptosis, a process of programmed cell death, in AML blast cells and lymphocytes. The researchers found that chemotherapy effectively induced apoptosis in leukemia cells while sparing lymphocytes, suggesting a targeted effect on the cancerous cells. They also found a correlation between the level of apoptosis in bone marrow blast cells and disease-free survival, suggesting that apoptosis could be a potential biomarker for treatment response.

Understanding Apoptosis in Leukemia Treatment

This research provides valuable insights into the mechanisms of chemotherapy in AML. The findings suggest that chemotherapy effectively induces apoptosis in leukemia cells, contributing to remission induction. This information could lead to the development of new therapeutic strategies that enhance apoptosis in leukemia cells and improve treatment outcomes for AML patients.

Navigating Cancer Treatment

Cancer treatment can be a challenging and complex journey. If you or a loved one is facing a cancer diagnosis, it is crucial to seek guidance from a qualified healthcare professional. A multidisciplinary team of specialists can provide personalized treatment plans, support, and guidance throughout the treatment process. Remember, you are not alone in this journey.

Dr.Camel's Conclusion

This research, like a camel trekking through the vast desert of cancer treatment, sheds light on the delicate balance between targeting cancerous cells and preserving healthy cells. It offers hope for AML patients by highlighting the potential of chemotherapy to induce apoptosis in leukemia cells and improve treatment outcomes.

Date :
  1. Date Completed 2006-07-10
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

16572429

DOI: Digital Object Identifier

10.1002/cyto.b.20105

SNS
PICO Info
in preparation
Languages

English

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