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Alefacept in combination with methotrexate for the treatment of psoriatic arthritis: results of a randomized, double-blind, placebo-controlled study.

Author: , GladmanDafna D, KeystoneEdward C, MeasePhilip J

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

Alefacept in combination with MTX may be an effective and safe treatment for PsA.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the efficacy and safety of alefacept in combination with methotrexate (MTX) for the treatment of psoriatic arthritis (PsA). METHODS: Patients were eligible for this randomized, double-blind, placebo-controlled trial if they were ages 18-70 years and had active PsA (> or = 3 s...See full text at original site
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引用元：
https://doi.org/10.1002/art.21870

データ提供：米国国立医学図書館（NLM）

A New Hope for Psoriatic Arthritis: Alefacept and Methotrexate

Psoriatic arthritis (PsA) is a chronic inflammatory condition that can cause significant pain and disability. This research explores the efficacy and safety of combining alefacept, a novel treatment for PsA, with methotrexate, a commonly used medication. This double-blind, placebo-controlled study aimed to evaluate the effectiveness of this combination therapy in alleviating PsA symptoms and improving quality of life for patients. The study found that the combination of alefacept and methotrexate led to a significant improvement in PsA symptoms compared to methotrexate alone, suggesting a potential benefit for patients with this debilitating condition.

A Promising Combination for PsA Management

The study demonstrated that alefacept, when combined with methotrexate, significantly improved PsA symptoms. Specifically, a higher proportion of patients in the alefacept group achieved a 20% improvement in disease activity compared to the placebo group. This finding suggests that alefacept could be a valuable addition to existing PsA treatment regimens.

Understanding the Potential Benefits and Risks

While this research offers promising insights, it's essential to understand that alefacept, like any medication, comes with potential side effects. Consult with a healthcare professional to weigh the potential benefits and risks based on your individual medical history and needs.

Dr. Camel's Conclusion

Just as a camel needs to carefully choose its path through the desert to avoid obstacles, treating PsA requires a careful consideration of various therapies. This research provides hope for patients with PsA, offering a potential combination therapy that can significantly improve symptoms. Remember, always consult with a qualified healthcare professional to determine the most suitable treatment plan for your specific needs.
Date :
  1. Date Completed 2006-08-04
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

16646026

DOI: Digital Object Identifier

10.1002/art.21870

Related Literature

Article Analysis
・Effective treatment of psoriatic arthritis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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