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Legionella: macrolides or quinolones?

Author: Pedro-BotetL, YuV L

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Quinolones may be more effective than macrolides in treating Legionnaires' disease, based on in-vitro and animal studies. Observational studies also suggest that quinolones may lead to a faster recovery and fewer complications compared to macrolides. However, no randomized trials have compared the clinical efficacy of these drugs.
Paper Details　
Original Abstract of the Article :
Following the first outbreaks of legionnaire's disease, erythromycin emerged as the treatment of choice without the foundation of rigorous clinical trials. The number of therapeutic failures with erythromycin, as well as the side-effects and drug interactions, led to the consideration of other drugs...See full text at original site
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引用元：
https://doi.org/10.1111/j.1469-0691.2006.01394.x

データ提供：米国国立医学図書館（NLM）

Legionnaires' Disease: Finding the Right Weapon in the Fight

Legionnaires' disease, a severe form of pneumonia, can be a formidable foe. This research explores the effectiveness of macrolides and quinolones in treating this bacterial infection. The authors review both in-vitro and animal studies comparing the efficacy of these two classes of antibiotics. The research suggests that quinolones may be more effective than macrolides in treating Legionnaires' disease, based on evidence from in-vitro and animal studies. However, the authors emphasize the need for more robust clinical trials to confirm these findings.

Quinolones: A Potential Advantage in Treating Legionnaires' Disease

The research suggests that quinolones may be more effective than macrolides in treating Legionnaires' disease, based on preclinical studies. However, further clinical trials are needed to confirm these findings and establish the optimal treatment strategy for this serious infection.

The Importance of Evidence-Based Treatment

This research highlights the importance of evidence-based medicine in choosing the most effective treatment for Legionnaires' disease. The authors emphasize the need for rigorous clinical trials to determine the optimal therapeutic approach for this challenging infection.

Dr.Camel's Conclusion

The battle against Legionnaires' disease is ongoing. This research explores the potential benefits of quinolones in treating this infection, but further research is needed to determine the best weapon in our arsenal. The quest for effective treatments for Legionnaires' disease continues in the vast desert of medical research.

Date :
  1. Date Completed 2006-06-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16669926

DOI: Digital Object Identifier

10.1111/j.1469-0691.2006.01394.x

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