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Impact of haloperidol, a dopamine D2 antagonist, on cognition and mood.

Author: ChristensenBruce K, RemingtonGary, SaeediHuma

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Haloperidol, an antipsychotic drug, blocks dopamine D(2) receptors. This study found that a single dose of haloperidol led to significant deficits in sustained attention, reaction time, and speed of information processing, as well as contentment, anger, and confusion in healthy participants. These cognitive and mood effects were most noticeable 4 hours after administration and were dose-dependent.
Paper Details　
Original Abstract of the Article :
Blocking dopamine (DA) D(2) receptors is the sine qua non of antipsychotic activity. However, it is this same process that accounts for their liability to produce extrapyramidal symptoms (EPS) and hyperprolactinemia. It remains unclear, though, whether there are other negative consequences that migh...See full text at original site
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引用元：
https://doi.org/10.1016/j.schres.2006.03.033

データ提供：米国国立医学図書館（NLM）

Haloperidol's Impact on Cognition and Mood: Unveiling the Effects of Dopamine D2 Antagonism

The human brain, a sprawling desert of interconnected neurons, operates on a delicate balance of neurotransmitters. This research investigates the impact of haloperidol, a dopamine D2 antagonist, on cognition and mood. Imagine a bustling marketplace of neurotransmitters, where dopamine plays a crucial role in regulating our thoughts, feelings, and actions. This study examines the effects of blocking dopamine D2 receptors, a key mechanism of action for antipsychotic medications, on cognitive function and emotional well-being.

Unveiling the Hidden Costs of Dopamine D2 Blockade

This study reveals a significant negative impact of haloperidol on sustained attention, reaction time, and speed of information processing, suggesting that dopamine D2 antagonism can have substantial cognitive consequences. The researchers also found that haloperidol negatively affected mood, leading to decreased contentment and increased feelings of anger and confusion. These findings highlight the complex interplay between dopamine and higher cognitive and emotional functions, emphasizing the potential trade-offs associated with blocking dopamine D2 receptors.

Navigating the Complexities of Antipsychotic Treatment

This study underscores the importance of considering the potential cognitive and emotional side effects of antipsychotic medications, particularly those that act as dopamine D2 antagonists. The researchers' findings suggest that the benefits of these medications in treating psychosis must be carefully weighed against the potential negative impact on cognitive function and mood. This research encourages us to continue exploring alternative treatment options and personalized strategies to mitigate the potential side effects of antipsychotic medications.

Dr.Camel's Conclusion

This study provides valuable insights into the multifaceted effects of dopamine D2 antagonism on cognition and mood. The researchers' meticulous analysis of the impact of haloperidol on these domains highlights the importance of carefully considering the potential trade-offs associated with blocking dopamine D2 receptors. This research encourages us to remain vigilant in our pursuit of safer and more effective treatments for mental health conditions, always striving to improve patient outcomes and quality of life.
Date :
  1. Date Completed 2006-12-28
  2. Date Revised 2016-05-26
Further Info :

Pubmed ID

16679001

DOI: Digital Object Identifier

10.1016/j.schres.2006.03.033

SNS
PICO Info
in preparation
Languages

English

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