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NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies.

Author: McGeerEdith G, McGeerPatrick L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review examines the link between inflammation and Alzheimer disease. Traditional NSAIDs have been shown to be effective in reducing pathology in AD transgenic mice. Clinical investigations are ongoing, but further research is needed to determine the efficacy of NSAIDs in treating Alzheimer disease.
Paper Details　
Original Abstract of the Article :
This review reports correlations between four independent fields related to inflammation and Alzheimer disease: fundamental pathology, epidemiology, transgenic animal studies and clinical trials. Activated microglia, along with a spectrum of inflammatory mediators, have been identified in associatio...See full text at original site
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引用元：
https://doi.org/10.1016/j.neurobiolaging.2006.03.013

データ提供：米国国立医学図書館（NLM）

NSAIDs: A Potential Remedy for Alzheimer's Disease?

The [Alzheimer's disease] landscape is a daunting desert, shrouded in mystery. This research digs into the potential of [NSAIDs] as a potential remedy for this debilitating disease. The authors investigate the link between [inflammation] and Alzheimer's disease by analyzing data from [epidemiology, animal models, and clinical trials]. Their findings suggest that certain NSAIDs might offer protection against Alzheimer's disease, although the results of clinical trials have been mixed. This study highlights the intricate relationship between inflammation, the brain, and Alzheimer's disease, offering valuable insights for future research and treatment strategies.

NSAIDs: A Promise of Relief for Alzheimer's Disease

While the results of clinical trials have been mixed, this research offers a glimmer of hope for Alzheimer's disease. The study suggests that certain NSAIDs may play a role in protecting against this devastating disease. This finding, like a patch of green in the desert, encourages further exploration of the potential benefits of NSAIDs in managing Alzheimer's disease.

Understanding Alzheimer's Disease: A Complex Journey

Alzheimer's disease, like a shifting sand dune, presents a complex and challenging landscape. This research explores the intricate relationship between inflammation, NSAIDs, and this disease. While some NSAIDs may offer potential benefits, it's crucial to consult a healthcare professional to understand the risks and benefits of taking these medications. Remember, staying informed and seeking expert guidance is essential when navigating the challenges of Alzheimer's disease.

Dr.Camel's Conclusion

This study delves into the complex relationship between inflammation, NSAIDs, and Alzheimer's disease. It highlights the need for more research to fully understand the potential benefits and risks of NSAIDs in managing this devastating condition. It's a reminder that the quest for solutions in Alzheimer's disease is an ongoing journey, like a camel's trek across the vast desert.

Date :
  1. Date Completed 2007-05-31
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

16697488

DOI: Digital Object Identifier

10.1016/j.neurobiolaging.2006.03.013

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Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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