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Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects.

Author: FurlanAndrea D, Mailis-GagnonAngela, SandovalJuan A, TunksEldon

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Opioids are effective for pain and functional outcomes in patients with chronic noncancer pain (CNCP), particularly strong opioids. A meta-analysis of 41 randomized trials involving 6019 patients with various types of CNCP found that opioids outperformed placebo and were superior to other medications for pain relief, especially strong opioids. However, the high dropout rates highlight the need for longer-term studies and strategies to minimize side effects.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Chronic noncancer pain (CNCP) is a major health problem, for which opioids provide one treatment option. However, evidence is needed about side effects, efficacy, and risk of misuse or addiction. METHODS: This meta-analysis was carried out with these objectives: to compare the efficacy ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459894/

データ提供：米国国立医学図書館（NLM）

Opioids for Chronic Pain: A Balancing Act

Imagine a traveler navigating a treacherous desert, seeking relief from pain and exhaustion. Opioids, a class of medications, have long been used to provide pain relief, but they also come with potential risks and side effects.

This meta-analysis aimed to assess the effectiveness and side effects of opioids for chronic noncancer pain (CNCP). The researchers analyzed data from 41 randomized controlled trials involving over 6,000 patients. They found that opioids, both weak and strong, were more effective than placebo for pain and functional outcomes in patients with nociceptive, neuropathic, or fibromyalgia pain. However, strong opioids were significantly superior to other pain medications like naproxen and nortriptyline, only for pain relief. The most common side effects of opioids were constipation and nausea.

Opioids: A Double-Edged Sword for Chronic Pain

This meta-analysis reveals the complex nature of opioid therapy for chronic pain. While opioids can provide significant relief, their use also carries risks and potential for misuse. It's like navigating a desert with a powerful but unpredictable beast – the benefits are significant, but the potential dangers must be carefully considered.

Navigating Opioid Therapy with Caution

This research emphasizes the need for a careful and personalized approach to opioid therapy for chronic pain. Clinicians must weigh the potential benefits against the risks, closely monitor patients for side effects, and work collaboratively with patients to develop safe and effective treatment plans.

Dr. Camel's Conclusion

Opioid therapy for chronic pain is a delicate balancing act, requiring a keen understanding of both the potential benefits and risks. Like a desert traveler navigating a treacherous landscape, we must approach this therapy with caution, awareness, and a commitment to patient safety and well-being.

Date :
  1. Date Completed 2006-05-25
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

16717269

DOI: Digital Object Identifier

PMC1459894

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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