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[Effects of acitretin on the expression of signaling pathway-related genes in epidermal squamous-cell carcinoma cells].

Author: CaiSui-qing, ChenLi-rong, ZhengMin

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Acitretin, a retinoid used to treat skin cancers, inhibits the expression of STAT3, cyclin D1, and p42/44MAPK in an epidermal squamous-cell carcinoma cell line. In a study using A431 cells, acitretin downregulated the mRNA and protein levels of these signaling pathway-related genes in a time-dependent manner, suggesting that acitretin's therapeutic effect may involve modulation of these pathways.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To study the effects of acitretin on the expression of signaling pathway-related genes in an epidermal squamous-cell carcinoma cell line. METHODS: The mRNA expression levels of STAT3, cyclin D1 and p42/44MAPK were detected in a human epidermal carcinoma cell line A431 by RT-PCR. Their ex...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/16737614

データ提供：米国国立医学図書館（NLM）

Acitretin's Effects on Signaling Pathways in Epidermal Squamous-Cell Carcinoma

[Acitretin], a retinoid, is used to treat [epidermal squamous-cell carcinoma (ESCC)]. This research investigates the effects of acitretin on the expression of key signaling pathway-related genes in ESCC cells. The authors found that acitretin significantly inhibited the expression of [STAT3] and [cyclin D1] in ESCC cells, suggesting that acitretin might act by modulating these signaling pathways. This is akin to discovering a hidden wellspring in the desert, uncovering a new mechanism by which acitretin may combat ESCC.

A New Perspective on Acitretin's Action

This research sheds light on the potential mechanisms by which acitretin exerts its therapeutic effects. It suggests that acitretin might act by targeting specific signaling pathways involved in ESCC cell growth and proliferation. It's like finding a new roadmap that reveals the pathways by which acitretin navigates the desert of ESCC and ultimately leads to its demise.

Health and Lifestyle Implications

Understanding the molecular mechanisms of acitretin's action could lead to the development of more targeted and effective therapies for ESCC. It's like unlocking the secrets of a hidden oasis, revealing new strategies for treating this debilitating disease.

Dr. Camel's Conclusion

ESCC is a formidable opponent, like a sandstorm that threatens to engulf us. This research, like a beacon in the desert, unveils a new understanding of acitretin's action, offering hope for better treatment strategies and ultimately, victory over this disease.

Date :
  1. Date Completed 2007-12-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16737614

DOI: Digital Object Identifier

16737614

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Languages

Chinese

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