Two-dimensional and three-dimensional imaging show ciclesonide has high lung deposition and peripheral distribution: a nonrandomized study in healthy volunteers.

Author: BethkeThomas D, BoudreauRobert J, DavidsonPatricia, DrollmannAnton, HasselquistBruce E, LeachChet L, WurstWilhelm

Paper Details 
Original Abstract of the Article :
Drug deposition is an important factor that contributes to safety and efficacy outcomes of inhaled steroid therapy. Ciclesonide is a nonhalogenated, inhaled corticosteroid under investigation for the treatment of asthma. Therefore, this study was performed to assess lung deposition of ciclesonide. T...See full text at original site
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引用元:
https://doi.org/10.1089/jam.2006.19.117

データ提供:米国国立医学図書館(NLM)

Ciclesonide: A Deep Dive into Lung Deposition and Distribution

This research explores the world of pharmacokinetics, specifically focusing on the deposition and distribution of ciclesonide, an inhaled corticosteroid. The study uses sophisticated imaging techniques to visualize how ciclesonide is delivered to the lungs, providing valuable insights into the effectiveness and safety of this drug for asthma treatment.

Ciclesonide's Effective Lung Delivery

The study found that ciclesonide, when administered through a metered-dose inhaler, exhibits high lung deposition exceeding 50%. Interestingly, the drug showed a greater distribution in the peripheral regions of the lungs compared to the central regions. This suggests that ciclesonide effectively reaches the areas where asthma often manifests, potentially maximizing its therapeutic effect.

Breathing Easier with Ciclesonide

These findings provide a strong foundation for the use of ciclesonide as an effective treatment for asthma. Its high lung deposition and targeted distribution to the peripheral regions suggest that it may be more effective at reducing inflammation and improving lung function. This could be a welcome relief for individuals struggling with asthma, as they might experience fewer side effects and improved symptom control.

Dr.Camel's Conclusion

This study illustrates the importance of understanding drug delivery mechanisms, comparing it to the way a caravan navigates the desert - ensuring supplies reach their destination. Ciclesonide, with its efficient lung deposition, offers a promising approach to asthma management.

Date :
  1. Date Completed 2006-08-10
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

16796536

DOI: Digital Object Identifier

10.1089/jam.2006.19.117

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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