Surface and bulk properties of two anionic amphiphilic penicillins in a selective solvent.

Author: AnteloLuis T, BarbosaSilvia, MosqueraVíctor, TaboadaPablo

Paper Details 
Original Abstract of the Article :
The surface physicochemical properties of two anionic penicillins-cloxacillin and dicloxacillin-in mixed ethanol-water solvent were investigated by surface tension and dynamic light scattering (DLS). The data were analyzed according to the treatment of the Derjaguin-Landau-Verwey-Overbeek (DLVO) the...See full text at original site
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引用元:
https://doi.org/10.1021/jp062161g

データ提供:米国国立医学図書館(NLM)

Penicillins: A Journey into the Realm of Surface Chemistry

The world of pharmaceuticals often involves intricate interactions at the molecular level. This research explores the surface and bulk properties of two anionic penicillins, cloxacillin and dicloxacillin, in a mixed ethanol-water solvent. The researchers used surface tension and dynamic light scattering techniques to investigate the behavior of these drugs at the air-water interface. They discovered that the presence of ethanol influenced the surface activity, bulk properties, and stability of the penicillins, with dicloxacillin exhibiting a stronger tendency to escape from the aqueous environment to the air-water monolayer.

A Molecular Dance in the Desert: The Role of Ethanol

The findings suggest that the addition of ethanol alters the behavior of the penicillins at the molecular level. Ethanol, as a solvent, influences the dielectric constant of the mixture, leading to changes in the surface activity of the penicillins. This research provides valuable insights into the interactions between these drugs and their environment, a crucial aspect in understanding their effectiveness and potential side effects.

The Intricate World of Pharmaceutical Interactions

This research highlights the importance of understanding the complex interactions between drugs and their surrounding environment. The findings suggest that the presence of solvents, such as ethanol, can significantly influence the behavior of drugs at the molecular level. This knowledge can inform the development of more effective and safer pharmaceuticals, ensuring that these medications are delivered to their intended targets with minimal unintended effects. Just like the desert holds a vast array of chemical compounds, the world of pharmaceuticals is full of intricate interactions waiting to be unraveled.

Dr.Camel's Conclusion

This study provides a fascinating glimpse into the molecular interactions of penicillins, highlighting the influence of solvents on their surface and bulk properties. The findings underscore the importance of considering the complex environment in which drugs operate, offering valuable insights for future pharmaceutical research and development. Just like the desert holds a vast array of chemical compounds, the world of pharmaceuticals is full of intricate interactions waiting to be unraveled.

Date :
  1. Date Completed 2007-09-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16836332

DOI: Digital Object Identifier

10.1021/jp062161g

Related Literature

SNS
PICO Info
in preparation
Languages

English

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