Paper Details

  1. Home
  2. Paper Details

Effects of acitretin on spermatogenesis of rats.

Author: AltintasL, ApaydinR, BayramgürlerD, BilenN, MüezzinogluB, SengörB

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Acitretin, a retinoid, was investigated for its effects on spermatogenesis in rats. No statistically significant effects were observed on spermatogenesis after 8 and 16 weeks of standard or high-dose acitretin administration.
Paper Details　
Original Abstract of the Article :
In this experimental study the possible effects of the acitretin on the spermatogenesis of the rats were investigated histopathologically. Thirty-nine male adult Wistar albino rats were divided into 3 groups as two experimental groups and one control group. The first group consisting 14 rats were ap...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1468-3083.2006.01573.x

データ提供：米国国立医学図書館（NLM）

Acitretin and Spermatogenesis: A Tale of Two Doses

Acitretin, a medication used to treat psoriasis, has been a subject of debate regarding its effects on male reproductive health. This study set out to explore the potential impact of acitretin on spermatogenesis, the process of sperm production, in rats. The researchers administered two doses of acitretin to separate groups of rats and compared the results to a control group. They carefully examined the testes of the rats for any changes in spermatogenetic activity, organization, and other parameters.

No Evidence of Acitretin’s Impact on Sperm Production

The results of this study showed no statistically significant differences between the groups, even when analyzing the high dose of acitretin. This suggests that acitretin, within the tested dosages, does not appear to have a negative impact on sperm production in rats.

Navigating the Desert of Uncertainty

Just like navigating a desert with a compass, understanding the potential effects of medications is crucial for ensuring our well-being. While this study sheds light on the possible effects of acitretin on spermatogenesis in rats, further research is needed to confirm these findings in humans. Remember, it’s always wise to consult with a healthcare professional before making any changes to your medication regimen.

Dr.Camel's Conclusion

This study offers some reassurance regarding the potential impact of acitretin on spermatogenesis in rats. However, it’s important to remember that further research is needed to fully understand the effects of this medication in humans. Always consult with a healthcare professional before making any decisions about your medications.

Date :
  1. Date Completed 2006-11-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16836496

DOI: Digital Object Identifier

10.1111/j.1468-3083.2006.01573.x

Related Literature

Article Analysis
・Effects of acitretin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.