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Testosterone aromatization and cognition in women: a randomized, placebo-controlled trial.

Author: BellRobin J, DavisSusan R, DonathSusan, GoldstatRebecca, KulkarniJayashri, PapaliaMary-Anne, SavageGreg, ShahSonal

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

In postmenopausal women treated with testosterone, aromatase inhibition did not affect cognition. However, the study may have lacked sufficient power to detect subtle changes.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To explore whether inhibition of the conversion of testosterone to estradiol modifies the effects of testosterone on cognition in 61 healthy, estrogen-treated postmenopausal women. DESIGN: Seventy-six postmenopausal women using transdermal estrogen for at least 8 weeks, with a serum tota...See full text at original site
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引用元：
https://doi.org/10.1097/01.gme.0000227333.50867.4e

データ提供：米国国立医学図書館（NLM）

Testosterone and Cognition in Postmenopausal Women: A Complex Relationship

The role of hormones, particularly testosterone, in cognitive function is a complex and intriguing area of research. This study investigated the effects of testosterone therapy on cognition in postmenopausal women, specifically exploring the impact of inhibiting the conversion of testosterone to estradiol. A group of 61 women were randomly assigned to receive either testosterone therapy with an aromatase inhibitor (letrozole) or testosterone therapy with a placebo.

Testosterone Therapy Shows Positive Cognitive Effects but More Research is Needed

The study found that testosterone therapy, regardless of the aromatase inhibitor, led to significant improvements in visual and verbal memory, as well as simple concentration, in the postmenopausal women. However, the study also highlighted the need for more research to investigate the subtle effects of testosterone on cognition and the potential role of aromatase inhibition.

Navigating the Hormonal Landscape of Cognition

This research provides valuable insights into the complex relationship between testosterone and cognition in postmenopausal women. It highlights the potential benefits of testosterone therapy for cognitive function, but also emphasizes the need for ongoing research to fully understand the mechanisms at play and optimize treatment strategies.

Dr. Camel's Conclusion

Like a camel navigating a desert landscape, understanding the relationship between testosterone and cognition in women requires careful observation and exploration. This research provides a starting point, but further research is needed to map this complex hormonal landscape.

Date :
  1. Date Completed 2006-10-19
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

16837882

DOI: Digital Object Identifier

10.1097/01.gme.0000227333.50867.4e

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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