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Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial.

Author: BrowneP, ConnorD J, LopezJ, PetersenR B, SabbaghM N, SparksD L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Atorvastatin therapy may be beneficial for mild-to-moderate Alzheimer's disease patients, but the level of benefit may be influenced by the severity of cognitive impairment, circulating cholesterol levels, or apolipoprotein E genotype.
Paper Details　
Original Abstract of the Article :
CONTEXT: Recent evidence suggests that treatment of mild-to-moderate Alzheimer's disease (AD) with atorvastatin provides significant benefit on the Alzheimer Disease Assessment Scale-Cognitive (ADAS-cog) after 6 months. OBJECTIVE: To determine if benefit on ADAS-cog performance produced by atorvast...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0404.2006.00690.x

データ提供：米国国立医学図書館（NLM）

Atorvastatin and Alzheimer's Disease: A Complex Relationship

Alzheimer's disease, a progressive neurodegenerative disorder, can feel as vast and mysterious as a desert with hidden secrets. This study delves into the complex relationship between atorvastatin, a cholesterol-lowering medication, and Alzheimer's disease. The authors conducted a double-blind, placebo-controlled trial to evaluate the potential benefits of atorvastatin in individuals with mild-to-moderate Alzheimer's disease.

Atorvastatin: A Potential Benefit in Early Alzheimer's Disease

The study revealed that atorvastatin therapy was associated with a significant positive effect on cognitive performance in individuals with mild-to-moderate Alzheimer's disease. This benefit was more pronounced in individuals with higher baseline cognitive function, elevated cholesterol levels, or who carried the apolipoprotein-E-4 allele.

Health Implications and Practical Applications

This study suggests that atorvastatin therapy may be beneficial for individuals with mild-to-moderate Alzheimer's disease, particularly those with specific risk factors. However, it's crucial to consult with a healthcare professional to determine if atorvastatin is the right treatment option for each individual. Just as a camel navigates a desert, we must carefully consider all factors when making healthcare decisions.

Dr. Camel's Conclusion

This study sheds light on the complex interplay between cholesterol levels, apolipoprotein E genotype, and Alzheimer's disease. While atorvastatin shows potential benefits in early stages of the disease, further research is needed to fully understand its mechanisms and optimize its use. It's a reminder that we must embrace a nuanced approach to healthcare, acknowledging the individual variations and complexities of disease.

Date :
  1. Date Completed 2006-10-02
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

16866904

DOI: Digital Object Identifier

10.1111/j.1600-0404.2006.00690.x

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Languages

English

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