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A randomized trial of deep-brain stimulation for Parkinson's disease.

Author: , BötzelKai, DanielsChristine, DeuschlGünther, DeutschländerAngela, DillmannUlrich, EisnerWilhelm, GruberDoreen, HamelWolfgang, HerzogJan, HilkerRüdiger, KlebeStephan, KlossManja, KoyJan, KrackPaul, KrauseMartin, KupschAndreas, LorenzDelia, LorenzlStefan, MehdornH Maximilian, MoringlaneJean Richard, OertelWolfgang, PinskerMarcus O, PoeweWerner, ReichmannHeinz, ReussAlexander, Schade-BrittingerCarmen, SchneiderGerd-Helge, SchnitzlerAlfons, SchäferHelmut, SteudeUlrich, SturmVolker, TimmermannLars, TronnierVolker, TrottenbergThomas, VogesJürgen, VolkmannJens, WojteckiLars, WolfElisabeth

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Neurostimulation of the subthalamic nucleus was more effective than medical management alone in patients with severe motor complications of Parkinson's disease. However, serious adverse events, including a fatal intracerebral hemorrhage, were more common with neurostimulation.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Neurostimulation of the subthalamic nucleus reduces levodopa-related motor complications in advanced Parkinson's disease. We compared this treatment plus medication with medical management. METHODS: In this randomized-pairs trial, we enrolled 156 patients with advanced Parkinson's disea...See full text at original site
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引用元：
https://doi.org/10.1056/NEJMoa060281

データ提供：米国国立医学図書館（NLM）

Deep-Brain Stimulation: A Promising Treatment for Parkinson's Disease

This research explores the effectiveness of [deep-brain stimulation] for [Parkinson's disease]. Think of it like guiding a camel through a desert storm: Deep-brain stimulation aims to [regulate brain activity] to [reduce motor symptoms] associated with [Parkinson's disease]. The researchers conducted a [randomized-pairs trial] involving [156 patients] with [advanced Parkinson's disease] and found that [deep-brain stimulation] resulted in [greater improvements] in [quality of life] and [motor symptoms] compared to [medication alone].

Deep-Brain Stimulation Shows Promise for Parkinson's Treatment

This study provides encouraging results for [deep-brain stimulation] as a treatment for [Parkinson's disease]. The researchers found that [deep-brain stimulation] led to [significant improvements] in [mobility], [activities of daily living], [emotional well-being], and [overall quality of life]. While [serious adverse events] were more common with [deep-brain stimulation], the [overall frequency of adverse events] was [higher] in the [medication alone] group.

Living Well with Parkinson's Disease

This research offers hope for [Parkinson's disease] patients by highlighting a [potential treatment option] that can significantly improve their [quality of life]. It's important to remember that [Parkinson's disease] is a [complex condition], and the [best treatment plan] will vary depending on the individual's needs. Consult with your doctor to discuss [treatment options] and to develop a [personalized plan] that addresses your specific symptoms and goals.

Dr. Camel's Conclusion

This research represents a significant step forward in the [treatment of Parkinson's disease]. Deep-brain stimulation offers a [new hope] for [Parkinson's patients] by providing [relief from debilitating symptoms] and [improving quality of life]. It's a reminder that [medical science] is constantly evolving and finding new ways to [combat disease] and [improve patient outcomes].

Date :
  1. Date Completed 2006-09-05
  2. Date Revised 2023-11-20
Further Info :

Pubmed ID

16943402

DOI: Digital Object Identifier

10.1056/NEJMoa060281

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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