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An orally active selective androgen receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate.

Author: ChangWilliam, ChapmanMark S, FinnPatricia D, HongMei Hua, LópezFrancisco J, MarschkeKeith B, MinerJeffrey N, Negro-VilarAndres, RosenJon, SchraderWilliam, TurnerRussell, ViverosHumberto, ZhiLin, van OeverenArjan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

LGD2226, a nonsteroidal, nonaromatizable, highly selective androgen receptor (AR) ligand, was found to exhibit anabolic activity on muscle and bone with reduced impact on prostate growth in rodent models. This suggests that orally active, nonsteroidal selective androgen receptor modulators may be useful therapeutics for enhancing muscle, bone, and sexual function.
Paper Details　
Original Abstract of the Article :
A number of conditions, including osteoporosis, frailty, and sexual dysfunction in both men and women have been improved using androgens. However, androgens are not widely used for these indications because of the side effects associated with these drugs. We describe an androgen receptor (AR) ligand...See full text at original site
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引用元：
https://doi.org/10.1210/en.2006-0793

データ提供：米国国立医学図書館（NLM）

A New Oasis in the Desert of Androgen Therapy: LGD2226, a Selective Androgen Receptor Modulator

Androgens, like water in a desert, play a vital role in maintaining bone, muscle, and sexual function. However, traditional androgen therapies can have unwanted side effects. This study introduces LGD2226, a selective androgen receptor modulator (SARM), which offers a promising alternative, like finding a new source of water that is both beneficial and safe.

Navigating the Desert: Finding a Balanced Approach to Androgen Therapy

LGD2226, a nonsteroidal SARM, specifically targets the androgen receptor with minimal impact on other receptors. This is like having a camel guide that knows the best path through the desert, avoiding potential hazards and ensuring a safe journey. The study demonstrates the potential benefits of LGD2226 in improving bone, muscle, and sexual function with reduced impact on the prostate, a major concern with traditional androgen therapies.

A New Horizon of Hope: SARMs for Bone, Muscle, and Sexual Health

This study highlights the potential of SARMs like LGD2226 for treating various conditions related to bone, muscle, and sexual function. This is like discovering a new oasis in the desert, offering a much-needed source of water and resources for those struggling with these conditions. Further research is needed to explore the long-term efficacy and safety of SARMs, but these early findings offer a promising glimpse into the future of androgen therapy.

Dr. Camel's Conclusion

This study introduces LGD2226, a promising new SARM with the potential to revolutionize androgen therapy. It is like finding a new oasis in the desert of medical research, offering a safe and effective way to manage conditions related to bone, muscle, and sexual health. This discovery opens new doors for research and development, paving the way for more targeted and effective treatments in the future.
Date :
  1. Date Completed 2007-02-13
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17023534

DOI: Digital Object Identifier

10.1210/en.2006-0793

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Languages

English

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