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Dose-dependent effects of oral dronedarone on the circadian variation of RR and QT intervals in healthy subjects: implications for antiarrhythmic actions.

Author: GaudChristine, RadzikDavid, SarmaJonnalagedda Sm, SinghBramah N, WadhaniNitin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Dronedarone is a medication that can be used to treat irregular heart rhythms. This study found that dronedarone prolonged the QT interval in a dose-dependent manner. The QTc interval, which is adjusted for heart rate, was also significantly prolonged. These findings suggest that dronedarone may be a useful alternative to amiodarone, another anti-arrhythmic drug, as it does not have the same iodine-mediated side effects.
Paper Details　
Original Abstract of the Article :
Dronedarone, a non-iodinated benzofuran derivative, was developed as a potentially less toxic alternative to amiodarone. This study describes Holter data of dronedarone in humans. Five groups of healthy subjects were given 1 of 5 oral doses of dronedarone in a twice-daily regimen or placebo. Holter ...See full text at original site
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引用元：
https://doi.org/10.1177/1074248406290678

データ提供：米国国立医学図書館（NLM）

Dronedarone's Effect on the Circadian Rhythm of the Heart: A Rhythmic Beat

The human heart beats to a circadian rhythm, like a desert wind that blows in a predictable pattern. This research explores the effects of dronedarone, a potential alternative to amiodarone, on the circadian variation of heart rate and electrical activity. The authors used Holter monitoring to measure the heart's rhythm in healthy subjects, revealing that dronedarone prolonged both heart rate and QT intervals in a dose-dependent manner. However, it did not alter the natural circadian pattern of these rhythms. This indicates that dronedarone may offer a unique advantage over amiodarone, potentially having fewer side effects.

A Rhythm of Hope for Antiarrhythmic Treatment

This study provides a rhythmic beat of hope for those seeking safe and effective antiarrhythmic treatment. Dronedarone's ability to prolong heart rate and QT intervals without disrupting the natural circadian rhythm is a significant finding. This suggests that dronedarone could be a promising alternative to amiodarone, potentially offering a more harmonious approach to managing heart rhythm disorders.

Staying in Tune with Your Heart's Rhythm

Staying in tune with your heart's rhythm is crucial for overall health. While this study suggests a potential benefit of dronedarone, it's essential to consult with a healthcare professional for personalized advice. As with any medication, understanding the potential risks and benefits is crucial for navigating the complex world of heart health.

Dr.Camel's Conclusion

This research offers a refreshing perspective on the treatment of heart rhythm disorders. It explores the intricate interplay between medications and the body's natural rhythms, suggesting that a more harmonious approach may be possible. Dronedarone holds promise as a potential alternative to amiodarone, but further research is needed to fully understand its long-term effects and ensure its safety and efficacy.

Date :
  1. Date Completed 2007-02-16
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

17056831

DOI: Digital Object Identifier

10.1177/1074248406290678

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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