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Inhibitory effects of ticlopidine on platelet function as assessed by three different methods.
Author: Cuyun-LiraO, KanekoM, OhnishiM, OzakiY, SatohK, TakafutaT, YatomiY
Original Abstract of the Article :
The inhibitory effects of ticlopidine on platelet function were evaluated in 18 healthy male volunteers using three different platelet function tests. Three methods include the recently developed small collagen-beads method, which evaluates the platelet response in whole blood samples under shear st...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.ejps.2006.09.003
データ提供:米国国立医学図書館(NLM)
Measuring the Impact of Ticlopidine on Platelet Function
In the vast landscape of medicine, platelet function plays a crucial role in maintaining the delicate balance of blood clotting. Ticlopidine, an antiplatelet drug, is commonly used to prevent blood clots, but its effects on platelet function can vary depending on the method of measurement. This study investigates the inhibitory effects of ticlopidine on platelet function using three different methods, aiming to determine the most accurate and reliable approach.
Comparing Platelet Function Tests: A Quest for Accuracy
The study compared the results of three platelet function tests: the small collagen-beads method, conventional platelet aggregometry, and a cone-plate viscometer. While all three methods revealed ticlopidine's inhibitory effects on platelet function, the study found that the collagen-beads method was particularly effective at detecting ticlopidine's impact on platelet retention rates, especially at higher retention rates. This method's use of whole blood samples under shear stress conditions adds to its practicality. The findings highlight the importance of choosing the appropriate platelet function test to accurately assess the effects of antiplatelet drugs.
Optimizing Antiplatelet Therapy for Patient Safety
This study serves as a reminder that the choice of platelet function test can significantly impact the interpretation of antiplatelet drug effects. The study's findings underscore the importance of using a test that is both accurate and reliable to monitor the effects of ticlopidine therapy, ensuring optimal patient safety and minimizing potential risks. As we continue to explore the intricate world of platelet function, we must remain diligent in our quest for the most effective and safe methods for monitoring antiplatelet therapy.
Dr. Camel's Conclusion
Platelet function is a delicate dance, and understanding its nuances is crucial in managing blood clotting disorders. This study, like a skilled camel trainer, guides us towards the most accurate and reliable methods for measuring platelet function. The findings highlight the importance of precision in our assessments, ensuring that we can navigate the complexities of platelet function with confidence and provide the best possible care for our patients. As we continue to explore the mysteries of blood clotting, we must embrace the pursuit of knowledge and strive for excellence in our clinical practice.
Date :
- Date Completed 2007-02-23
- Date Revised 2013-11-21
Further Info :
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