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Are sulfonylureas passé?

Author: FeinglosMark N, GreenJennifer B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Sulfonylureas are commonly used to manage type 2 diabetes. While effective in the short term, they have limitations, including potential for hypoglycemia and weight gain. Newer agents like glimepiride may have less detrimental effects on the myocardium.
Paper Details　
Original Abstract of the Article :
Sulfonylureas and similarly acting rapid insulin secretagogues have long been available to manage type 2 diabetes. These agents have a well understood mechanism of action and are in large part well tolerated. However, sulfonylurea therapy is unlikely to sustain adequate long-term glycemic control an...See full text at original site
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引用元：
https://doi.org/10.1007/s11892-006-0008-9

データ提供：米国国立医学図書館（NLM）

Sulfonylureas: Still Relevant in the Management of Type 2 Diabetes?

Type 2 diabetes, a chronic disease characterized by high blood sugar levels, affects millions worldwide. This research examines the role of sulfonylureas, a class of medications that have long been used to manage type 2 diabetes, and discusses their potential benefits and limitations in the context of newer treatment options.

Evaluating Sulfonylureas: Benefits and Limitations

The review acknowledges the well-understood mechanism of action and generally good tolerability of sulfonylureas. However, the authors highlight the limitations of these drugs, including their potential for long-term glycemic control, side effects such as hypoglycemia and weight gain, and potential adverse effects on ischemic preconditioning and cardiac outcomes.

Navigating Diabetes Management: Sulfonylureas in Combination Therapy

The review concludes that while sulfonylureas can be effective as part of combination therapy for diabetes management, newer agents are often preferred due to their improved safety profile and potential for long-term glycemic control.

Dr.Camel's Conclusion

The journey through the desert of type 2 diabetes requires the right tools for the trek. While sulfonylureas have long been a reliable companion, newer medications offer potential advantages for managing this challenging condition. Choosing the appropriate treatment approach should be based on individual patient factors and a comprehensive understanding of the benefits and limitations of different medications.

Date :
  1. Date Completed 2007-02-26
  2. Date Revised 2019-11-10
Further Info :

Pubmed ID

17076998

DOI: Digital Object Identifier

10.1007/s11892-006-0008-9

Related Literature

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・Side Effects of glimepiride
SNS
PICO Info
in preparation
Languages

English

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