The effects of inhaled budesonide and formoterol in combination and alone when given directly after allergen challenge.

Author: DuongMyLinh, EvansMichelle, GauvreauGail, HowieKaren, KillianKieran, O'ByrnePaul M, ObminskiGeorge, StrinichTara, WatsonRichard

Paper Details 
Original Abstract of the Article :
BACKGROUND: The use of combination inhaled budesonide and formoterol as maintenance and reliever therapy significantly improves the risk and the time to exacerbations in asthma. OBJECTIVES: To explore the mechanisms underlying the effect of the reliever dose on exacerbations by examining the effect...See full text at original site
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引用元:
https://doi.org/10.1016/j.jaci.2006.10.018

データ提供:米国国立医学図書館(NLM)

The Combination Therapy for Asthma Relief

The world of asthma research is a constant quest to find better ways to control this chronic respiratory disease. In this particular study, researchers sought to delve into the mechanisms behind the effectiveness of a combination therapy involving inhaled budesonide and formoterol. This therapy is known for its ability to reduce the frequency and severity of asthma exacerbations, and the researchers aimed to understand how the reliever dose of this combination therapy works. They carried out a randomized, double-blind crossover study, meticulously comparing the effects of the combination therapy to its individual components and to placebo. The results provided valuable insights into the effectiveness of the combination therapy and how it interacts with the body to improve asthma control.

A Closer Look at Asthma Relief

The findings of this study suggest that a single dose of the combination therapy is more effective than its individual components in attenuating the allergen-induced late airway response, which is a key feature of asthma. The researchers observed that the combination therapy not only reduced the severity of airway inflammation but also decreased airway hyperresponsiveness, which is a characteristic of asthma. These findings further support the use of combination therapy as a valuable tool for managing asthma.

The Role of Combination Therapy in Managing Asthma

This research provides further evidence for the benefits of combination therapy for asthma management. The combination of budesonide and formoterol is a powerful tool for preventing and treating asthma exacerbations. If you are living with asthma, talk to your doctor about whether this combination therapy is appropriate for you. By adopting a proactive approach to asthma management, you can help minimize the impact of this chronic condition on your daily life.

Dr. Camel's Conclusion

This study underscores the complex nature of asthma and the effectiveness of combination therapies in achieving better control of this chronic condition. It's a reminder that the quest for optimal asthma management is an ongoing journey, and this research provides valuable insights that contribute to our understanding of how to best alleviate the symptoms and improve the quality of life for those living with this disease.

Date :
  1. Date Completed 2007-03-12
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

17141859

DOI: Digital Object Identifier

10.1016/j.jaci.2006.10.018

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