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Effects of recombinant human granulocyte colony-stimulating factor on leucopenia in zidovudine-treated patients with AIDS and AIDS related complex, a phase I/II study.

Author: DannerS A, LangeJ M, van LeeuwenR, van OersR H, van der WouwP A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Recombinant human granulocyte colony-stimulating factor (G-CSF) is a drug that is used to stimulate the production of neutrophils, a type of white blood cell. In a study of 12 patients with zidovudine-associated neutropenia, G-CSF increased the number of circulating neutrophils at relatively low doses and with few side effects.
Paper Details　
Original Abstract of the Article :
Twelve male patients, eight with the acquired immunodeficiency syndrome (AIDS) and four with AIDS related complex (ARC), who had zidovudine associated neutropenia (less than 1 x 10(9) neutrophils/l) were treated with recombinant human granulocyte colony-stimulating factor (G-CSF) in a phase I/II stu...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2141.1991.tb04443.x

データ提供：米国国立医学図書館（NLM）

Recombinant Human Granulocyte Colony-Stimulating Factor: A Promising Treatment for Zidovudine-Associated Neutropenia in AIDS Patients

This phase I/II study investigates the effectiveness of recombinant human granulocyte colony-stimulating factor (G-CSF) in treating zidovudine-associated neutropenia in patients with AIDS and AIDS-related complex (ARC). Twelve male patients, eight with AIDS and four with ARC, were treated with daily subcutaneous injections of G-CSF in escalating doses. The study found that G-CSF significantly increased neutrophil counts in these patients at relatively low doses and with minimal side effects. While two patients discontinued the study due to complications, the overall results demonstrate the potential of G-CSF as a safe and effective treatment for zidovudine-associated neutropenia in AIDS patients.

G-CSF: A Promising Treatment for Zidovudine-Associated Neutropenia

The study highlights the potential of recombinant human granulocyte colony-stimulating factor (G-CSF) as a safe and effective treatment for zidovudine-associated neutropenia in AIDS patients. This could lead to improved management of this common side effect and potentially enhance the quality of life for individuals with AIDS.

Navigating the Challenges of AIDS: A Journey of Hope and Progress

AIDS is a complex and challenging condition, but ongoing research and advancements in treatment options offer hope for patients. This study exemplifies the importance of exploring new therapeutic approaches to address the various complications associated with AIDS, ultimately improving the lives of individuals affected by this disease. It’s like a camel finding a source of water in a parched desert, a beacon of hope in a challenging journey.

Dr. Camel's Conclusion

Just as a camel adapts to the harsh desert environment, researchers are constantly adapting to the challenges of AIDS. This study offers a glimmer of hope in the ongoing quest to find effective and safe treatments for this complex disease. The development of G-CSF as a treatment for zidovudine-associated neutropenia is a testament to the progress being made in combating AIDS.

Date :
  1. Date Completed 1991-09-24
  2. Date Revised 2019-07-04
Further Info :

Pubmed ID

1714756

DOI: Digital Object Identifier

10.1111/j.1365-2141.1991.tb04443.x

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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